Neurons are born throughout adulthood in the hippocampus and show enhanced plasticity compared with mature neurons. However, there are conflicting reports on whether or not young neurons contribute to performance in behavioral tasks, and there is no clear relationship between the timing of maturation of young neurons and the duration of neurogenesis reduction in studies showing behavioral defic...

BACKGROUND Spatial and space-time scan statistics are widely used in disease surveillance to identify geographical areas of elevated disease risk and for the early detection of disease outbreaks. With a scan statistic, a scanning window of variable location and size moves across the map to evaluate thousands of overlapping windows as potential clusters, adjusting for the multiple testing. Almos...

* 511(12 Reversal Mechanism of Multidrug Resistance by Verapamil: Di rect Binding of Verapamil to P-Glycoprotein on Specific:Sites and Transport of Verapamil Outward across the Plasma Membrane of K562/ADM Cells. Keisuke Yusa and Takashi Tsuruo. 5007 Lysis of Antigenically Unrelated Tumor Cells Mediated by Lyt 2* Splenic T-Cells from Melphalan-cured MOPC-315 Tumor Bear ers. Edward Barker,James A...

The axiom that prevention is better than cure is especially true for a serious disease such as cancer for which therapy is expensive and seldom fully effective. However, it is only for some cancers that the major determinants are known and for which primary prevention programs are likely to result in substantial reduction in incidence. Past efforts at primary prevention have not been very succe...

Combinations of neuronal determinants and/or small-molecules such as Forskolin (Fk) can be used to convert different cell types into neurons. As Fk is known to activate cAMP-dependent pathways including CREB-activity, we aimed here to determine the role of CREB in reprogramming - including its temporal profile. We show that transient expression of the dominant-positive CREB-VP16 followed by its...

BACKGROUND Cancer screening reduces cancer mortality when early detection allows successful treatment of otherwise fatal disease. There are a variety of trial designs used to find the best screening test. In a series screening trial design, the decision to conduct the second test is based on the results of the first test. Thus, the estimates of diagnostic accuracy for the second test are condit...