نتایج جستجو برای: early clinical exposure
تعداد نتایج: 2004987 فیلتر نتایج به سال:
IMPORTANCE The role of microbial exposure during early life in the development of type 1 diabetes mellitus is unclear. OBJECTIVE To investigate whether animal contact and other microbial exposures during infancy are associated with the development of preclinical and clinical type 1 diabetes. DESIGN, SETTING, AND PARTICIPANTS A birth cohort of children with HLA antigen-DQB1-conferred suscept...
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...
AIMS To investigate whether exposure to cobalt in cobalt plants has any measurable effect on the cardiovascular system. METHODS Occupational, cross sectional study, using a self administered questionnaire, blood pressure measurement, electrocardiography, and laboratory tests in which 203 male workers with at least one year of exposure to cobalt and 94 unexposed controls participated. Echocard...
background: organic nitrates relax all kinds of smooth muscle , not only vascular smooth muscle , a fact that has allowed the use of these drugs to treat many different aliments. objective.-the purpuse of this study was to examine prosepectively benefical effects , if any, of sublingual nitroglycerin on the pain of renal colic. design.- prospective , randomised , double blind, placebo- contoled...
RATIONALE The timing and duration of traffic-related air pollution (TRAP) exposure may be important for childhood wheezing and asthma development. OBJECTIVES We examined the relationship between TRAP exposure and longitudinal wheezing phenotypes and asthma at age 7 years. METHODS Children completed clinical examinations annually from age 1 year through age 4 years and age 7 years. Parental-...
Prenatal exposure to sodium valproate (VPA), a widely used anti-epileptic drug, is related to a series of dysfunctions, such as deficits in language and communication. Clinical and animal studies have indicated that the effects of VPA are related to the concentration and to the exposure window, while the neurobehavioral effects of VPA have received limited research attention. In the current stu...
BACKGROUND There are concerns regarding early years' training for junior doctors in Trauma & Orthopaedic Surgery (T&O) in the United Kingdom. Our primary objective was to audit the clinical activities undertaken by junior doctors working in Trauma & Orthopaedic (T&O) surgery in the National Health Service (NHS) in a typical workweek. A secondary objective was to audit the clinical exposure of j...
ingested corrosive substances produce different injuries, ranging from minor gastro esophageal burns to death, depending on the agent type, amount, concentration, and duration of substance exposure. the purpose of this study was to investigate the outcomes and different causes of mortality in patients ingesting caustic substances. in a prospective study, between april 1999 and january 2006, a t...
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