Recent studies have suggested an association between several channulopathy diseases. However, the mechanism remains unclear. The aim of this case was to demonstrate the relation between Brugada Syndrome (BrS) and Early Repolarization Syndrome (ERS). We presented herein a 46_year_old women with no familial history of sudden death. She was hospitalized for ventricular tachycardia with a lipothymi...

Membrane current responses to sudden potential changes were recorded in solutions of various [K](o) on 52 internodal cells of Nitella clavata. The membrane current after sudden depolarization had a component sensitive to [K](o) which increased with time from 0.3 to 2.0 s and remained steady thereafter. This late current became zero at values of E and [K](o) which suggests that the current was n...

In contrast to the local axons of GABA neurons of the cortex and hippocampus, lateral hypothalamic neurons containing melanin concentrating hormone (MCH) and GABA send long axons throughout the brain and play key roles in energy homeostasis and mental status. In adults, MCH neurons maintain a hyperpolarized membrane potential and most of the synaptic input is inhibitory. In contrast, we found t...

Abstract When spin rotating devices are used in an electron accelerator ring the stochastic depolarization caused by synchrotron radiation becomes issue. Special design of optics is required order to minimize harmful effect depolarization. Ring adjustments which help called matching. In this lecture formalism for deriving matching conditions presented. Then, derived examples a rotator based on ...

This review continues a series of reviews on the analysis compounds with cardioprotective properties in number biaromatic structures, which include range sodium channel blockers. Among voltage-gated channels, Nav1.5 isoform is most abundant heart. Sodium blockers have historically been called "class I antiarrhythmics". this type, structure mainly late current belonging to Id subclass antiarrhyt...

The contributions of gamma-aminobutyric acid (GABA) receptors to posttetanic excitation of CA1 pyramidal neurons in rat hippocampal slices were studied using extracellular and intracellular recording techniques. Synaptic responses were evoked on tetanic stimulation (100-200 Hz, 40-100 pulses) applied in stratum radiatum close (300-600 microm) to the recording site. Under control conditions, tet...

OF THESIS CORRELATION BETWEEN ALTERNANS OF EARLY AND LATE PHASES OF VENTRICULAR ACTION POTENTIAL Several studies suggest that action potential duration (APD) alternans play an important role in initiation of arrhythmias, while less is known about the alternans of early phases of action potential (AP) and phase relation between the two. Transmembrane potentials recorded from swine and canine ven...

Early events of stimulus-response coupling in polymorphonuclear leukocytes (PMNL) reportedly include membrane depolarization as a necessary antecedent to oxidative responses. However, depolarization by nonspecific means (ionophores) is insufficient to elicit an oxidative burst. This apparent conflict might be related to whether depolarization is due to membrane receptor-mediated stimulation of ...

nur77, an immediate-early gene that encodes an orphan nuclear receptor, is rapidly and transiently induced by nerve growth factor (NGF) stimulation or membrane depolarization in the rat pheochromocytoma-derived cell line PC12. The Nur77 protein can act as a potent transcription activator and may function to regulate the expression of downstream genes in response to extracellular stimuli. We sho...