While many p53-deficient cell types are impaired in global genomic nucleotide excision repair of cyclobutane pyrimidine dimers (CPDs), human epidermal keratinocytes expressing human papillomavirus type 16 E6 and E7 are p53 deficient and yet maintain repair of CPD. We hypothesized that the p53 homolog, p63, may participate in governing global repair instead of p53 in keratinocytes. Following ult...

Two intraperitoneal injections of either infectious or non-infectious rabbit papilloma suspensions actively immunize rabbits against papillomatosis. The capacity of the non-infectious suspensions to immunize is considered as evidence that they contain papilloma virus even though none can be demonstrated by the usual infection test.

objective(s): to investigate the expression of human papilloma virus (hpv) l1 capsid protein, and human telomerase rna component (hterc) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   materials and methods: a total of 309 patients were recruited and cervical exfoliated cells were collected. immunocytochemistry was employed to detect hpv l1 capsid p...

Viruses are the accepted cause of many important cancers including cancers of the cervix and anogenital area, the liver, some lymphomas, head and neck cancers and indirectly human immunodeficiency virus associated cancers. For over 50 years, there have been serious attempts to identify viruses which may have a role in breast cancer. Despite these efforts, the establishment of conclusive evidenc...

sirtuin protein SIRT1 is a well studied and highly complex NAD + dependent class III histone deacetylase that has seemingly diverse functions in metabolism, aging and cancer. SIRT1 deacetylates several downstream effector proteins including KU70, NBS1, the FOXO transcription factor family, and p53, several of which are in response to DNA damage events occurring within the cell [1]. Regulation o...