The concept that one could replace a body part from another of the (autograft) or even person (homograft) has been around for millennia. In fact, autogenous skin flaps were carried out as far back sixteenth century. But it is only in 20th century better understanding immunology clarified reasons observation homograft failure, due to groundbreaking work Billingham, Brent, and Medawar. Using an i...

Objectives. Febrile seizures recur frequently. Factors increasing the risk of febrile seizure recurrence include young age at onset, family history of febrile seizures, previous recurrent febrile seizures, time lapse since previous seizure <6 months, relative low temperature at the initial seizure, multiple type initial seizure, and frequent febrile illnesses. Prevention of seizure recurrences ...

Methods for genetically mapping the end points of tandem -1plicaticEns c the rII region of bacteriophage T4D are presented. Analysis of ten duplications indicates (1) that the position of duplication end points and therefore the length of the duplicated segment differ in strains of independent origin; (2) that there is a direct relationship between segregation frequency and length; (3) that seg...

Extracellular S468R mutation of the epidermal growth factor receptor (EGFR) was recently identified as the cause of resistance to cetuximab, a widely used drug in colorectal cancer treatment. Here, we have determined the binding free energies of cetuximab's Fab VH-VL domains and endogenous EGF ligand to wild type and S468R EGFR by high-throughput molecular dynamics. The results show that the mu...

In the nematode Caenorhabditis elegans mutants in the gene unc-15 ( I ) affect the muscle protein paramyosin (WATERSTON, FISHPOOL and BRENNER 1977). We have characterized 20 ethyl methanesulfonate-induced mutations in essential genes closely linked to unc-15. These lethals defined 16 new complememtation groups. In the 0.65 map-unit interval around unc-I5 defined by dpy-14 and unc-56, seven newl...

1.Shared decision-making, a dialogue between patients and their care team that includes full disclosure of all testing treatment options, discussion the risks benefits those options and, importantly, engagement patient to express own goals, is particularly relevant in management conditions such as hypertrophic cardiomyopathy (HCM).2.Although primary cardiology can initiate evaluation, treatment...

The rates of maternal morbidity and mortality in the United States demand a comprehensive approach to assessing pregnancy-related risks. Numerous medical nonmedical factors contribute mortality. Reducing number women who experience pregnancy requires identifying which are at greatest risk initiating appropriate interventions early reproductive life course. purpose this Consult is educate all he...

We report two cases of a 52 and 32-year-old males treated with cefotaxime. On day 23 and 28 of the treatment, the patients have manifested a clinical picture of fever, pruriginous skin rash and facial edema. Blood tests showed marked eosinophilia and atypical lymphocytosis for both patients and only hepatic cytolysis in the second patient. Cefotaxime was discontinued and the clinico-biological ...