Craniosynostosis (CS) is the premature fusion of cranial sutures during embryonic development, and this results in intracranial pressure skull deformities. Thyrotoxicosis, specifically maternal hyperthyroidism, has been linked to development CS. Our lab currently validating an avian model thyroxine-induced CS study mechanism involved thyroxine-enhanced ossification. We hypothesized that thyroxi...

Abstract Background Stem cell transplantation has been reported as one of the promising strategies to treat retinal degenerative diseases. But, application and role retina stem cells (RSCs) in treatment patients with diseases have not fully revealed. This study aimed investigate potential embryo-derived RSCs into vitreous cavity repairing damaged mice. Methods were isolated from Kunming mice E1...

Sequential thymidine radiograms from rats injected on days E16, E17, E18, and El9 and killed 2 hours after injection and at daily intervals up to day E22 were used to establish the site of origin, migratory route, and settling patterns of neurons of the nucleus reticularis tegmenti pontis and basal pontine gray. The nucleus reticularis tegmenti pontis neurons, which are produced predominantly o...

Monoclonal antibodies (mAbs) to rat neurofilament (NF) proteins NF-L, NF-M, and NF-H were used to examine the developmental programs of NF expression in rat embryos. The ability of these mAbs to recognize differentially phosphorylated states of NF-M and NF-H (Lee et al., 1987, the preceding paper) was exploited in order to examine the temporal and spatial patterns of NF phosphorylation during e...

Morphogenesis of the septal region was examined in normal rat embryos from embryonic day (E) 10 to E22. The greater part of the septal region is postulated to form from two separate anlagen which can be clearly distinguished in the telencephalon by E13 and E14. One lies in the anterior ventromedial wall and presumably forms the nucleus of the diagonal band, medial, lateral, and triangular septa...

Fetal repair of myelomeningocele (MMC) has been proven to be beneficial for the central nervous system development; however, the effect of fetal MMC repair on bladder function remains controversial. The objective of the present study was to establish an early timepoint for in utero MMC repair using a rat model, and to investigate the changes in bladder development subsequent to that interventio...

Abstract We evaluated the correlation between immunohistochemical BCL2, BCL2 E17, MCL1 (Bcl2-related protein family) and BAX (effector proapoptotic protein) expression intensity of staining in plasma cells (PC) MM patients (pts) who were eligible for autologous stem cell transplantation (ASCT) with DD4, CD8, FOXP3 positive Tregs lymphocytes bone marrow (BM) microenvironment, morphologic feature...

(Cell 180, 107–121.e1–e17; January 9, 2020) In our paper we showed that the periphery-to-center progression of lung fibrosis is driven by a TGF-β signaling loop activated mechanical tension in alveolar stem cells. It has come to attention Figure 5F image selected represent cells from stretched+GSK3008348 condition came non-stretched control was inadvertently mislabeled. This error now been corr...

(Immunity 51, 766–779.e1–e17; October 15, 2019) The proteomics data deposition for this study (located at ftp://massive.ucsd.edu/MSV000083991) has been corrected to include all MAPTAC-profiled alleles. complete dataset (including previously uploaded files) is now located under "updates/2020-10-05_JAbelin_e5cb28f1/.” An associated "README" file (at other/README_RawAndSearchFileLocation.txt) deta...

(Cell 182, 1519–1530.e1–e17; September 17, 2020) Our paper showed that spatiotemporal cAMP signaling is under the control of nanometer-sized domains shaped by phosphodiesterases, gating activation downstream effectors. Equations 1 and 2 were used to characterize spatial-temporal fluorescent diffusion. We have identified errors introduced into these equations when using Microsoft Word equation e...