We acclimated adult males of three Eremias lizards from different latitudes to 28 °C, 33 °Cor 38 °Cto examine whether temperature acclimation affects their thermal preference and tolerance and whether thermal preference and tolerance of these lizards correspond with their latitudinal distributions. Overall , selected body temperature ( Tsel) and viable temperature range (VTR) were both highest ...

Since the anti-inflammatory, antidiabetic and hypolipidemic effects of soy isoflavones may be mediated by activation of peroxisome proliferator-activated receptors (PPAR), the present study investigated whether the methanolic fractions obtained from soybean seeds (E1) and soybean seed coats with hypocotyls (E2) could influence PPARalpha, PPARgamma and PPARbeta/delta transcriptional activity. Th...

Rubella virus (RuV) infection of pregnant women can cause fetal death, miscarriage, or severe fetal malformations, and remains a significant health problem in much of the underdeveloped world. RuV is a small enveloped RNA virus that infects target cells by receptor-mediated endocytosis and low pH-dependent membrane fusion. The structure of the RuV E1 fusion protein was recently solved in its po...

The DF3/MUC1 gene is aberrantly overexpressed in human breast and other carcinomas. Previous studies have demonstrated that the DF3/MUC1 promoter/enhancer confers selective expression of diverse transgenes in MUC1-positive breast cancer cells. In this study, we show that an adenoviral vector (Ad.DF3-E1) in which the DF3/MUC1 promoter drives expression of E1A selectively replicates in MUC1-posit...

Human papillomaviruses (HPVs) are the causative agents of benign and malignant lesions of the epithelium. Despite their high prevalence, there is currently no antiviral drug for the treatment of HPV-induced lesions. The ATPase and helicase activities of the highly conserved E1 protein of HPV are essential for viral DNA replication and pathogenesis and hence are considered valid antiviral target...

High risk types of human papillomavirus, such as type 18 (HPV-18), cause cervical carcinoma, one of the most frequent causes of cancer death in women worldwide. DNA replication is one of the central processes in viral maintenance, and the machinery involved is an excellent target for the design of antiviral therapy. The papillomaviral DNA replication initiation protein E1 has origin recognition...

Large-scale QRPA calculations of the E1-strength are performed as a first attempt to microscopically derive the radiative neutron capture cross sections for the whole nuclear chart. A folding procedure is applied to the QRPA strength distribution to take the damping of the collective motion into account. It is shown that the resulting E1-strength function based on the SLy4 Skyrme force is in cl...

We have studied the structure of the Borromean nucleus Li via the Coulomb breakup with a Pb target at 70 MeV/nucleon. Momentum vectors of the breakup particles, Li and two neutrons, were measured in coincidence to reconstruct the B(E1) energy spectrum. The strong E1 transitions were observed at Erel ∼ 0.3 MeV with the B(E1)=1.42(18)efm (=4.5(6)W.u.), which is the largest E1 strength ever observ...

(2) For every equivalence relation E1 of X and for all sets x, y, z such that z ∈ [x](E1) and z ∈ [y](E1) holds [x](E1) = [y](E1). (3) For every partition P of X and for all sets x, y, z such that x ∈ P and y ∈ P and z ∈ x and z ∈ y holds x = y. (4) For all sets C, x such that C is a classification of X and x ∈ ⋃ C holds x ⊆ X . (5) For every set C such that C is a strong classification of X ho...

Targeting the activating enzymes (E1) of ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) has emerged as a promising anti-cancer strategy, possibly overcoming the ineffectiveness of proteasome inhibitors against solid tumors. Here, we report crystal structures of the yeast ubiquitin E1 (Uba1) with three adenosyl sulfamate inhibitors exhibiting different E1 specificities, which are all covalen...