Endothelial cell dysfunction is the early and key factor in the development of atherosclerosis. Atherosclerosis may be initiated by endothelial injury, which then leads to the proliferation of intimal smooth-muscle cells. Endothelin is present in plasma, perhaps as a result of spillover from the interface of endothelial and vascular smooth muscle1. Plasma endothelin concentrations are high in c...

Hypertriglyceridemia is a highly prevalent lipid abnormality and it is associated with atherosclerosis, with a growing body of evidence linking elevated triglycerides (TGs) with cardiovascular disease. The current major omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) combination, lowers serum TGs while often increasing levels of low-density lipoprotei...

Successful implementation of clinical guidelines for preventing complications of dyslipidemias has been an ongoing challenge. The article by Vinker and colleagues in this journal investigates the results of implementing risk-based guidelines for LDL (Low Density Lipoprotein) management in comparison to the prior approach of using the same LDL cutoff for patients at all levels of risk. Results s...

Diabetologists have long recognized the comorbid diseases of obesity, hypertension, and hyperlipidemia in their type 2 diabetic patients, and the necessity of treating these conditions in order to improve outcomes. Cardiovascular disease (CVD) is the number-one cause of death among patients with diabetes, and its prevention is at the forefront of modern diabetes care. The clustering of insulin ...

Familial hypercholesterolemia (FH) is the most common inherited form of dyslipidemia and a major cause of premature cardiovascular disease. Management of FH mainly relies on the efficiency of treatments that reduce plasma low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRs) have been suggested as emerging regulators of plasma LDL-C concentrations. Notably, there is...

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Ligands for the PPARs have been widely developed for the treatment of various diseases including dyslipidemias and diabetes. While targeting selective receptor activation is an established therapeutic approach for th...

Objectives:Both anemia and dyslipidemia are widely prevalent public health problems, especiallyin the Indian population. Associationof dyslipidemias were reported in some individual experimental animals. The study was planned to find thechanges serum lipid profile adult patients with anemia. Material methods:100 cases of (hemoglobin <13 g% men <12 women), 100 age sex matched healthy contr...