نتایج جستجو برای: dyskinesias
تعداد نتایج: 912 فیلتر نتایج به سال:
I read the interesting report by Olanow et al. regarding factors predictive of the development of levodopa (L-dopa)-induced dyskinesia and wearing-off in Parkinson’s disease. L-Dopa has been widely used for more than 40 years, but a dose-finding study was never performed. I congratulate the authors for addressing this very important issue of L-dopa dosing. Their study provides scientific ration...
The search for antiglutamatergic drugs useful in PD is burdened by great expectations and disappointing results. At least 35 years of literature production can be tracked, and overwhelming theoretical evidence suggests that antiglutamatergic drugs could or should be useful in PD, yet evidence of positive results is restricted to few decent, blinded studies and to a massive presentation of anecd...
The reduced movement repertoire of Parkinson's disease (PD) is mainly due to degeneration of nigrostriatal dopamine neurons. Restoration of dopamine transmission by levodopa (L-DOPA) relieves motor symptoms of PD but often causes disabling dyskinesias. Subchronic L-DOPA increases levels of adaptor protein p11 (S100A10) in dopaminoceptive neurons of the striatum. Using experimental mouse models ...
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