2 Although multiple pulse and multi-dimensional NMR techniques permit generation of off-diagonal density matrix elements and observation of complex coherence transfer processes, eventually the density operator returns to an equilibrium state in which all coherences (off-diagonal elements of the density operator) have decayed to zero and the populations of the energy levels of the system (diagon...

Localized (13)C NMR spectroscopy provides a new investigative tool for studying cerebral metabolism. The application of (13)C NMR spectroscopy to living intact humans and animals presents the investigator with a number of unique challenges. This review provides in the first part a tutorial insight into the ingredients required for achieving a successful implementation of localized (13)C NMR spe...

BACKGROUND There is no comprehensive analytical technique to analyze N-acetylated metabolites in urine. Many of these compounds are involved in inborn errors of metabolism. In the present study, we examined the potential of proton nuclear magnetic resonance ((1)H-NMR) spectroscopy as a tool to identify and quantify N-acetylated metabolites in urine of patients with various inborn errors of meta...

Dynamic Nuclear Polarization (DNP) increases the sensitivity of NMR spectroscopy by using high frequency microwaves to transfer the polarization of the electrons to the nuclear spins. The enhancement in NMR sensitivity can amount to a factor of well above one hundred, enabling faster data acquisition and greatly improved NMR measurements. With the increasing magnetic fields (up to 23T) used in ...

Nuclear magnetic resonance (NMR) spectroscopy, and particularly solid-state NMR spectroscopy, is a method of choice to study the structure and dynamics of both the lipid and the protein components of model and biological membranes. Different approaches have been developed to study these systems in which the restricted molecular motions result in broad NMR spectra. This contribution will first p...

On the basis of in situ MAS NMR technique under flow conditions,1-4 the combined in situ MAS NMR-UV/Vis spectroscopy5 has recently been developed to obtain complimentary information on solid catalysts and, therefore, to better elucidate the mechanism involved in heterogeneous catalysis. While NMR spectroscopy allows the identification of species on the working catalyst in more detail, UV/Vis sp...