Introduction: Oxygen-enhanced MRI (O2-MRI) of the lung is based on the T1-shortening effect of oxygen (O2) inhalation and provides combined information about pulmonary ventilation, perfusion, and diffusion [1–9]. Dynamic O2-MRI acquires (in each pixel) the signal time course influenced by the alternating administration of room air and O2. By fitting a model function (pixelwise) to the acquired ...

Dynamic Contrast Enhanced MRI (DCE-MRI) is today one of the most popular methods for tumor assessment. Several pharmacokinetic models have been proposed to analyze DCE-MRI. Most of them depend on an accurate arterial input function (AIF). We propose an automatic and versatile method to determine the AIF. The method has two stages, detection and segmentation, incorporating knowledge about artery...

Introduction: Dynamic Contrast-enhanced MRI (DCE-MRI) consists of a series of rapid T1-weighted imaging (seconds per scan; tens of scans) performed before, during, and after the administration of an intravenous contrast agent that reduces the T1 value of blood and thereby enhances the signal intensity. It has become a useful tool to study the perfusion, permeability and angiogenesis property in...

Collective cell behaviors in migration and force generation were studied at the mesoscopic-level using cells grown in a 3D extracellular matrix (ECM) simulating tissues. Magnetic resonance imaging (MRI) was applied to investigate dynamic cell mechanics at this level. MDCK, NBT2, and MEF cells were embedded in 3D ECM, forming clusters that then migrated and generated forces affecting the ECM. Th...

Real-time magnetic resonance imaging (RT-MRI) is a powerful tool to study the dynamics of vocal tract shaping during speech production. The dynamic articulators of interest include the surfaces of the lips, tongue, hard palate, soft palate, and pharyngeal airway. All of these are located at air-tissue interfaces and are vulnerable to MRI off-resonance effect due to magnetic susceptibility. In R...

OBJECTIVE To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance (MR) imaging with that of triple-phase multidetector-row computed tomography (MDCT) in the detection of liver metastasis. MATERIALS AND METHODS Our institutional review board approved this retrospective study and waived informed consent. The study population consisted of 51 patients with hepatic meta...

conclusion the possibility of malignancy is strongly indicated when additional nme lesions show linear or segmental enhancement on preoperative 3t dce-mri in patients with recently diagnosed breast cancer. results on histopathologic analysis of the 88 nme lesions, 73 (83%) were malignant and 15 (17%) were benign. lesion size did not differ significantly between malignant and benign lesions (p =...

In this paper we address the problem of dynamic MRI reconstruction from partially sampled K-space data. Our work is motivated by previous studies in this area that proposed exploiting the spatiotemporal correlation of the dynamic MRI sequence by posing the reconstruction problem as a least squares minimization regularized by sparsity and low-rank penalties. Ideally the sparsity and low-rank pen...

Inflammation plays an important role in progression and rupture of atherosclerotic plaque. Dynamic contrast-enhanced MRI has been proposed as a tool to evaluate inflammation in vivo by measuring the transfer constant and partial plasma volume, which are influenced by inflammation. This study sought to demonstrate the ability of dynamic contrast-enhanced MRI to provide localized measurements of ...

Introduction: In dynamic contrast-enhanced (DCE-) MRI studies, it is necessary to obtain estimates of initial (i.e. native) and dynamic T1 values in order to quantify contrast agent concentrations, [CA]. The variable flip angle (VFA) method [1], which employs spoiled gradient echo data acquired using at least two different flip angles, is a T1 and M0 (a variable including the proton density, ga...