Employing Dynamic Discrete Dislocation Plasticity (D3P), an elastodynamic analysis of the shielding of a stationary crack tip by dislocations is studied. Dislocations are generated via FrankRead sources, and make a negligible contribution to the shielding of the crack tip, whereas dislocations generated at the crack tip via homogeneous nucleation dominate the shielding. Their effect is found to...

In the past, patients with uniocular cataracts who underwent cataract extraction were not able to tolerate aphakic spectacles due to 30% magnification of visual images thus giving rise to diplopia. The other alternative was to use contact lens which needed motivation. Some could not tolerate contact lens and its magnification of 5% to 7%. These failures eventually led to the idea of intraocular...

Ergonomic practice increases the productivity, quality, and longevity of the dermatologic surgeon. When used properly, magnification devices can be ergonomic and beneficial additions to the dermatologic surgeon's practice. Herein, we review the available magnification options for the dermatologic surgeon and evaluate the options based on cost, design, and functional advantages and disadvantages...

Background: Work-related musculoskeletal disorders are the most important problems in the health workforce. These discomforts cause many working days losses, increase absenteeism from work, and impose annual economic costs. Awkward posture is the most important factor among the risk factors for work-related musculoskeletal disorders. This study aimed at implementing an interventional ergonomic ...

Correlative light/electron microscopy (CLEM) combines the power of light microscopy to search large areas for fluorescently-tagged live cells/regions of interest and transmission electron microscopy (TEM) to image the same specimen at high magnification for ultrastructural characterization. CLEM methods are essential to observe dynamic processes such as organelle biogenesis and intracellular tr...

Birth Factors and Retinal Vascular Caliber in a Twin Study To the Editor: I read with interest the data from the Twins Eye Study in Tasmania demonstrating associations between birth factors and retinal vascular caliber.1 From these findings, the authors suggest that fetal growth may have adverse influence on the microcirculation. Low growth parameters at birth may not be specific and sensitive ...

The present paper deals with the mixed mode fracture analysis of a weakened orthotropic half-plane with multiple cracks propagation. The orthotropic half-plane contains Volterra type glide and climb edge dislocations. It is assumed that the medium is under in-plane loading conditions. The distributed dislocation technique is used to obtain integral equations for the dynamic problem of multiple ...

Forkhead box O (FoxO) transcription factors FoxO1, FoxO3a, FoxO4 and FoxO6, the mammalian orthologs of Caenorhabditis elegans DAF-16, are emerging as an important family of proteins that modulate the expression of genes involved in apoptosis, the cell cycle, DNA damage repair, oxidative stress, cell differentiation, glucose metabolism and other cellular functions. FoxO proteins are regulated by...