In the present note, we give a simple general proof for the existence of solutions of the following two types of variational problems: PROBLEM A. To minimize fa F(x> u, • • • , Du)dx over a subspace VofW>*(tt). PROBLEM B. TO minimize ƒ« F(x, w, • • • , Du)dx for u in V with / a G(x, u, • • • , D^u)dx^c. The solution of the first problem yields a weak solution of a corresponding elliptic boundar...

A bstract At colliders massive long-lived charged particles could be revealed through their anomalously large ionisation energy loss dE/dx . In this paper we explore a class of scenarios in which the LLPs are particularly boosted, owing to production from decay heavy parent resonance. Such give rise unique signatures as compared traditionally considered new-physics benchmarks. We demonstrate th...

Pancreatitis-associated ascitic fluid (PAAF) is known to contribute to the progression of acute pancreatitis (AP). We have investigated the capability of PAAF to activate the expression of MCP-1 in pancreatic acinar cells and the involvement of MAPK, NF-kappaB and STAT3 as downstream signalling transduction pathways. The actions of dexamethasone (Dx) and N-acetylcysteine (NAC) on the PAAF's aci...

The development of anticoagulants for treating patients with atherothrombotic disorders of the arterial circulatory system has focused, either directly or indirectly, on thrombin - a pleuripotential effector enzyme with prothrombotic and proinflammatory properties. The pivotal role of factor (f) Xa in thrombin generation, coupled with its direct cellular effects and widely recognized limitation...

Bacteria able to generate electricity in microbial fuel cells (MFCs) are of great interest, but there are few strains capable of high power production in these systems. Here we report that the phototrophic purple nonsulfur bacterium Rhodopseudomonas palustris DX-1, isolated from an MFC, produced electricity at higher power densities (2720 +/- 60 mW/m2) than mixed cultures in the same device. Wh...

En esta época, los periódicos son "una especie en peligro de extinción". Los lectores ahora se deleitan con "la potencia, la eficiencia y la elegancia tecnológica" de la información en Internet. No sólo los periódicos correrán esta suerte. Lo mismo sucederá con la radio y la televisión, engullidos por la enorme fuerza de la Red de redes. El autor de estos presagios es el senador John Kerry, que...

Heparin has been conventionally used as an anticoagulant for medical and surgical indications. Because factor Xa is an essential component of the prothrombinase complex and leads to the generation of thrombin, its inhibition has become a focus of newer antithrombotic drug development. The in vitro anticoagulant profile of DX-9065a, a synthetic direct factor Xa inhibitor, was studied using activ...