T he need for antithrombotic therapy after percutaneous coronary intervention (PCI) has been a troublesome issue for physicians for more than 20 years. With the advent of drug-eluting stents (DES), a minimum of 12 months of dual-antiplatelet therapy (DAPT) has become the norm. However, evolving stent and drug technologies are now set to change this dogma. In this article, we focus on the periop...