We address the problem of verifying timed properties of Markovian models of large populations of interacting agents, modelled as finite state automata. In particular, we focus on time-bounded properties of (random) individual agents specified by Deterministic Timed Automata (DTA) endowed with a single clock. Exploiting ideas from fluid approximation, we estimate the satisfaction probability of ...

Cell loss contributes to the pathogenesis of many inherited and acquired human diseases. We have developed a system to conditionally ablate cells of any lineage and developmental stage in the mouse by regulated expression of the diphtheria toxin A (DTA) gene by using tetracycline-responsive promoters. As an example of this approach, we targeted expression of DTA to the hearts of adult mice to m...

Immunization of mice with plasmids encoding xenogeneic orthologues of tumor differentiation antigens can break immune ignorance and tolerance to self and induce protective tumor immunity. We sought to improve on this strategy by combining xenogeneic DNA vaccination with an agonist anti-glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) monoclonal antibody (mAb), DT...

Renin-expressing cells are peculiar in that they act as differentiated cells, producing the hormone renin, while they also seem to act as progenitors for other renal cell types. As such, they may have functions independent of their ability to generate renin/angiotensin. To test this hypothesis, we ablated renin-expressing cells during development by placing diphtheria toxin A chain (DTA) under ...

In mobile wireless communication network, caching data items at the mobile clients is important to reduce the data access delay. However, efficient cache invalidation strategies are used to ensure the consistency between the data in the cache of mobile clients and at the database server. Servers use invalidation reports (IRs) to inform the mobile clients about data item updates. This paper prop...

With the potential of overcoming the memory and power wall, the many-core/multi-thread has become a trend in processor design area. However, this architecture is far from ripeness because it also companies with many challenges such as scalability and larger architecture design space compared with mono-core architectures. In many-core design space, Data-Flow based architectures are alternatives ...

-Iron doped Tin Selenide nanoparticles have been prepared by aqueous solution method in double distilled water at room temperature. All the chemicals used for this were of Analytical Reagent grade and of 99.999 % purity. Structural confirmation and particle size estimation of prepared SnSeFe0.5 Nanoparticles had been reported from Xray diffractogram obtained by CuKα radiation of wavelength 1.54...

The regeneration of mechanoreceptive hair cells occurs throughout life in non-mammalian vertebrates and allows them to recover from hearing and balance deficits that affect humans and other mammals permanently. The irreversibility of comparable deficits in mammals remains unexplained, but often has been attributed to steep embryonic declines in cellular production. However, recent results sugge...

A recent minimization technique, called hyper-minimization, permits reductions of language representations beyond the limits imposed by classical semantics-preserving minimization. Naturally, the semantics is not preserved by hyper-minimization; rather the reduced representation, which is called hyper-minimal, can accept a language that has a nite symmetric di erence to the language of the orig...

Toxoplasma gondii is a widespread parasite responsible for causing clinical diseases especially in pregnant and immunosuppressed individuals. Glucocorticoid-induced TNF receptor (GITR), which is also known as TNFRS18 and belongs to the TNF receptor superfamily, is found to be expressed in various cell types of the immune system and provides an important costimulatory signal for T cells and myel...