Exploring the design space of computer architectures generally consists of a trial-and-error procedure where several architectural configurations are evaluated by using simulation techniques. The final goal of the multiobjective design space exploration (DSE) process is the identification of architectural configurations optimal for a set of target objective functions, typically power consumptio...

Long-term depression (LTD) of synaptic signaling-lasting from tens of minutes to hours or longer-is a widespread form of synaptic plasticity in the brain. Neurons express diverse forms of LTD, including autaptic LTD (autLTD) observed in cultured hippocampal neurons, the mechanism of which remains unknown. We have recently reported that autaptic neurons express both endocannabinoid-mediated depo...

P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC usher. During pilus assembly, subunits are incorporated into the growing fiber via the donor-strand exchange (DSE) mechanism, whereby the chaperone's G1 beta-strand that compleme...

Transcription 'run-on' (TRO) analysis using permeabilized yeast cells indicates that transcription terminates between 180 and 380 bp downstream of the poly(A) site of the Schizosaccharomyces pombe ura4 gene. Two signals direct RNA polymerase II (pol II) to stop transcription: the previously identified 3' end formation signals located close to the poly(A) site and an additional downstream elemen...

Active imaging is a recently developed approach to model-based optimisation of imaging protocols. In the application we discuss here, a diffusion magnetic resonance imaging (dMRI) protocol is optimised for directly measuring aspects of biological tissue microstructure, subject to appropriate scanner hardware and acquisition time constraints. We present the theoretical basis for active imaging w...

VMODEX is an interactive visualization tool to support system-level Design Space Exploration (DSE) of MPSoC architectures. It provides insight into the search process of Multi-Objective Evolutionary Algorithms (MOEAs) that are typically used in the DSE process, and it facilitates the analysis of the DSE results. In this paper we extend VMODEX to enable designers to evaluate and compare the prop...

The Dyson-Schwinger equation (DSE) approach [1] to non-perturbative QCD modeling of hadrons and their interactions [2] combines truncated QCD equations of motion for propagators and vertices with infrared phenomenology fitted to a few key low-energy observables. Parameter-free predictions for other hadron properties and observables are then used to develop and test our understanding of hadron p...

RESEARCH DESIGN AND METHODSdSubjects were overweight/obese adults with type 2 diabetes mellitus (T2DM) with available fitness data at 4 years (n = 3,942).This clinical trial randomized subjects to DSE or ILI. DSE received standard care plus information three times per year related to diet, PA, and social support. ILI received weekly intervention contact for 6months that was reduced over the 4-y...

Abstract—This paper presents a Generalized Binary Integer Linear Programming (GBILP) method for optimal allocation of Phasor Measurement Units (PMUs) and to generate Dynamic State Estimation (DSE) solution with complete observability. The GBILP method is formulated with Zero Injection Bus (ZIB) constraints to reduce the number of locations for placement of PMUs in the case of normal and single ...

In this work we propose a comprehensive study of Digital Stent Enhancement (DSE), from the analysis of the requirements to the validation of the proposed solution. First, we derive the stent visualization requirements in the context of the clinical application and workflow. Then, we propose a DSE algorithm combining automatic detection, tracking, registration and contrast enhancement. The most ...