Fragment-based drug discovery (FBDD) has become a new strategy for drug discovery where lead compounds are evolved from small molecules. These fragments form low affinity interactions (dissociation constant (K(D)) = mM - μM) with protein targets, which require fragment screening methods of sufficient sensitivity. Weak affinity chromatography (WAC) is a promising new technology for fragment scre...

Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new a...

With the aim of understanding and identifying the traits which can be used as the suitable criteria for quick screening of the water deficit tolerant barley genotypes, an experiment based on randomized complete blocks design with three replications was conducted during two years to evaluate the biochemical responses of 20 barley genotypes to full irrigation and terminal water stress in the fie...

BACKGROUND The proportion of Australians aged over 65 years is increasing. Although screening and treatment for alcohol and drug issues has traditionally focused on those aged less than 65 years, there is growing evidence of alcohol and drug related harm among older people. OBJECTIVE This article broadly discusses our current understanding of alcohol and drug problems among people aged over 6...

INTRODUCTION We examined the prevalence of substance use disorders among homeless and vulnerably housed persons in three Canadian cities and its association with unmet health care needs and access to addiction treatment using baseline data from the Health and Housing in Transition Study. METHODS In 2009, 1191 homeless and vulnerably housed persons were recruited in Vancouver, Toronto, and Ott...

The New Mexico Department of Health and the New Mexico Medical Society invited organizations to participate in an initiative to promote clinical preventive services. The Clinical Preventive Initiative (CPI) focuses on the following interventions based on burden of illness, preventability of the condition, cost, current level of services, availability of leadership, and programmatic support: adu...

Urine drug screening can enhance workplace safety, monitor medication compliance, and detect drug abuse. Ordering and interpreting these tests requires an understanding of testing modalities, detection times for specific drugs, and common explanations for false-positive and false-negative results. Employment screening, federal regulations, unusual patient behavior, and risk patterns may prompt ...

OBJECTIVE To determine the prevalence of hepatitis C virus (HCV) among women seeking urgent gynecological care. METHODS Women were asked to complete a short self-assessment screening of HCV risk. Those answering yes to any of the screening questions were offered HCV testing and were asked to complete a more detailed questionnaire. RESULTS Among the 125 women who completed the screening ques...

The purpose of the current study was to examine differences in responses of older adults (age 55 and above) and younger adults (ages 18 to 54) to the Drug Abuse Problem Assessment for Primary Care (DAPA-PC), a computerized drug and alcohol abuse screening instrument developed for primary care settings. Data were collected from a diverse population of 327 adults presenting for care at The George...