نتایج جستجو برای: drug targeting
تعداد نتایج: 718057 فیلتر نتایج به سال:
Over the past years, emergence of various therapeutic approaches has attracted so much consideration, but chemotherapy remains most effective way in experimental practice. However, due to obstacles and difficulties, there is a limitation for additional clinical presentation outdated chemical treatments such as paclitaxel doxorubicin. Some barriers are severe side effects, profound cytotoxicity,...
Nanoparticle-based drug delivery systems allow improved solubility, enhanced stability in circulation and multi-functionality. These properties and functions open many doors and create new biomedical applications for targeting drugs or imaging agents directly to the disease site. Due to the high incidence and mortality of cancer, studies are concentrating on targeted drug delivery to the tumor....
We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug desig...
The central problem in cancer chemotherapy is the severe toxic side effects of anticancer drugs on healthy tissues. Invariably the side effects impose dose reduction, treatment delay, or discontinuance of therapy. To limit the adverse side effects of cancer chemotherapy on healthy organs, we proposed a drug delivery system (DDS) with specific targeting ligands for cancer cells. The proposed DDS...
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