Despite advances in contemporary chemotherapeutic strategies, long-term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this study, we used in vitro drug sensitivity data from the NCI-60 cell lines together with their Affymet...

Hypernatremia is defined as plasma Na+ concentration above 145 meq/L (often due to absolute body water loss and not to total sodium excess). Nevertheless, when kidney damage is present, as occurs in renal diseases, hepatic cirrhosis and congestive heart failure, total body sodium can be increased. The present study evaluates the relationship between hypernatremia and response to anesthetic drug...

Previous capture-recapture studies have estimated the prevalence of problem drug misuse in urban areas. This study estimates the prevalence in a rural county, Norfolk, using data from four sources: drug treatment agencies, probation, the arrest referral service, and police (drug-related crime with/without acquisitive crime). Careful consideration was given to methods of matching datasets and se...

The biological characteristics of hypersensitivity reactions of delayed type are, in general, much the same as are those of many tissue responses known to be mediated by antibodies. For example, the requirement for structural specificity on the par t of agents which evoke delayed allergic reactions seems to be just as exacting as is the case for antigens in classical immunological systems (1). ...

We examined the prevalence of multiple chemical sensitivities (MCS), a hypersensitivity to common chemical substances. We used a randomly selected sample of 1582 respondents from the Atlanta, Ga, standard metropolitan statistical area. We found that 12.6% of our sample reported the hypersensitivity and that, while the hypersensitivity is more common in women, it is experienced by both men and w...