Objective: The study aimed to solubilization of imidazole drugs of interest; ketoconazole (KT) and miconazole nitrate (MN), for enhancement of the water solubility, the dissolution properties and the antimycotic activity of these drugs. Method: Different solid dispersion methods were used to prepare various dispersion systems of KT and MN using polyethylene glycol 4000 (PEG 4000), polyethylene ...

Commercial tablets of Rosuvastatin Calcium exhibit unsatisfactory dissolution profiles and, consequently, problems of absorption and poor bioavailability. Rosuvastatin Calcium (RST), a poorly water-soluble 3-hydroxy3-methyl glut aryl CoA (HMG-CoA) Reductase inhibitor through inclusion complexation with hydroxy propyl β-cyclodextrin (HP-β-CD). The aim of this work was to develop Rosuvastatin Oro...

This investigation was aimed to improve the dissolution rate of the poorly soluble drug lovastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 200, Cab-O-Sil, sodium starch glycolate and...

The aim of the present work was to improve the solubility and dissolution rate of simvastatin (SIM), a drug used for the treatment of hyperlipidemia. Two systems were used: solid dispersions with PEG 4000 and PEG 6000 prepared using the fusion method in various ratio of 1:1, 1:3, and 1:5 and inclusion complexes with HP-β-cyclodextrin obtained by kneading method in a ratio of 1:1 with drug SIM. ...

PURPOSE The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. METHODS Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using crospovidone and microcrystalline cellulose as carrier. The physical state and interactions between the drug and carrier were characterized by Fourier tra...

The aim of the present study was to use factorial design to enhance the dissolution rate of nimesulide using solid binary systems with the hydrophilic carriers D-mannitol and polyethylene glycol (PEG 4000). Two-factor full factorial design was employed to investigate the effects of the drug/carrier ratio (X(1), 10 and 20%) and the method of　preparation (X(2), physical or co-melted mixture) on　t...

Objective(s) Ibuprofen is a problematic drug in tableting, and dissolution due to its poor solubility, hydrophobicity, and tendency to stick to surface. Because of the bad compaction behavior ibuprofen has to be granulated usually before tableting. However, it would be more satisfactory to obtain directly during the crystallization step crystalline particles that can be directly compressed and...

PURPOSE The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability. Therefore, the aim of the present study is to use in situ micronization process through pH change method to produce micron-size gliclazide particles for fast dissolution hence bet...