Use of biodegradable polymers as drug carriers mainly depends on desired degradation mechanisms and mechanical properties. Schizophrenia requires medication for months to years. Presently, all the existing atypical preparations have to be given daily. Non-compliance is a major problem in these patients. Risperidone is an atypical antipsychotic and drug of choice for the treatment of

The extensive use of polymers in medical and pharmaceutical applications including particularly packaging, medical devices, drug carriers and coatings has caused a substantial demand for the proper plasticizers. Although there are many plasticizers used in the chemical industry, only a few of them have been approved for pharmaceutical applications. The natural-based plasticizers characterized b...

In self-emulsification higher-energy micrometre and sub-micrometre oil droplets are spontaneously produced from larger ones and only a few such methods are known. They usually involve a one-time reduction in oil solubility in the continuous medium via changing temperature or solvents or a phase inversion in which the preferred curvature of the interfacial surfactant layer changes its sign. Here...

Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the ...

As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...

In addition to several well-known drug delivery strategies developed to facilitate effective chemotherapy with anticancer agents, some new approaches have been recently established, based on specific effects arising from the applications of ultrasound, magnetic and electric fields on drug delivery systems. This paper gives an overview of newly developed methods of drug delivery to tumors and of...

A multi-drug delivery system with sequential release based on titania nanotube arrays and polymer micelles as drug carriers is presented. Delivery of multiple water insoluble and soluble drugs required for combined local therapy is demonstrated.

Autonomous vehicles are being viewed with scepticism in their ability to improve safety and the driving experience. A critical issue with automated driving at this stage of its development is that it is not yet reliable and safe. When automated driving fails, or is limited, the autonomous mode disengages and the drivers are expected to resume manual driving. For this transition to occur safely,...