objective(s): this study evaluates the effect of substitution of microcrystalline cellulose (mcc) with ethylcellulose (ec) on mechanical and release characteristics of theophylline pellets. materials and methods: the effect of addition of ec was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. also the effect of type of granulating liqui...

Analyzing drug-drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug-drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network science. Our methodology uncovers functional drug categories along with the intr...

prescriptions written by general practitioners and medical specialists were studied and compared to determine the type, time of onset and clinical importance of drug-drug interactions (ddis) in an attempt to reduce further complications. in 2007, 28, 956, 638 prescriptions and 15, 610, 912 prescriptions in 2008 were filled by pharmacies affiliated with medical science universities. these prescr...

results: a total number of 117 patients were evaluated for adverse drug reactions, among them, 97 (82.9%) were considered to have immunological drug reactions. the most common symptoms of allergic drug reactions were morbilliform eruptions, serum sickness, dress (drug rash with eosinophilia and systemic symptoms), and toxic epidermal necrolysis. in 62 patients, anticonvulsant drugs had the prom...

conclusions as the results showed, the trend of activities was encouraging and some additional activities could be included to future programs relying on early-onset preventions. results summarizing the data led to three distinguished sections: 1) drug supply reduction activities; 2) drug demand reduction activities; 3) harm reduction activities. evidence acquisition in this report, authors gat...