objective: depression is a major health problem, which is not only underrecognized and undertreated, but is also associated with significant morbidity and mortality. it has been suggested that combination therapy rapidly reduces depressive symptoms in patients with moderate to severe depression and is more effective than monotherapy; but this suggestion remains controversial. serotonergic and n...

methamphetamine hydrochloride is a white to light brown crystalline powder, or clear chunky crystals resembling ice. the majority of street methamphetamine is produced in clandestine laboratories. the drug manufacturer states that patients should be informed that methamphetamine and amphetamine may impair the ability to engage in potentially hazardous activities such as driving a motor vehicle....

despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

concomitant use of several drugs by icu( intensive care unit) patients is often unavoidable. in these patients, pharmacokinetic drug interactions are very likely. the current study was designed to evaluate these interactions in patients hospitalized in an icu of a teaching hospital in tehran, iran. a questionnaire was designed and used to collect study data. the study was done in the icu of a t...

drug utilization evaluation (due) studies are designed to assess drug usage appropriateness. we aim to evaluate the drug utilization of intravenous ciprofloxacin and imipenem, two of the broad spectrum antibiotics that consume a significant proportion of our hospitals’ outlay, in different wards of a teaching hospital in zabol. during a 5 months period (december 2010 to may 2011), 263 patients ...

conclusions vancomycin, but not teicoplanin, can be considered an effective antibiotic of choice for controlling infections caused by mdr cons in gorgan, depending on the bacterial species. background coagulase-negative staphylococci (cons) are clinically important, especially in nosocomial and neonatal infections. the increasing emergence of glycopeptide-resistant cons has made these agents th...

this study was performed to assess the incidence of medication errors and irrational use of human albumin in two wards of our hospital and also aimed to evaluate the ability of pharmaceutical care center and pharmacists in improving patient care. albumin administration was evaluated for patients who received albumin during the study period, in gastroenterology and general surgery wards. the ind...

injection drug use has been the most growing rout of drug abuse in iran in the past decade and it has been responsible for the transmission of hiv virus in more than two third of cases. the aim of the present study was to determine the prevalence of hiv and hepatitis b in a group of idu cadavers and to compare the results to a group of cadavers of the normal population. in a case-control study ...

there are increasing reports of emergence of multiple drug resistant (mdr) acinetobacter spp in the world; however there are a few reports in our country. 145 a. baumannii isolates from distinct wards and children's medical center (cmc) in tehran were studied in order to find the profile of antibiotic resistance among them. 40.6% (59/145) of a. baumannii isolates were identified as mdr. overall...