Pentoxifylline potentiates the cytotoxicity of alkylating agents in preclinical models. In this study we sought to define the maximum tolerated dose (MTD) of N,N',N"-triethylenethiophosphoramide (thioTEPA) with pentoxifylline, and to estimate the antitumor response to this combination in previously treated breast cancer patients. Thirty-five previously treated advanced breast cancer patients re...

CONTEXT Quantification of the magnitudes of fluid resistance provided by water jets (currents) and their effect on energy expenditure during aquatic-treadmill walking is lacking in the scientific literature. OBJECTIVE To quantify the effect of water-jet intensity on jet velocity, drag force, and oxygen uptake (VO2) during aquatic-treadmill walking. DESIGN Descriptive and repeated measures. ...

BACKGROUND Cabozantinib inhibits mesenchymal-epithelial transition factor (MET) and vascular endothelial growth factor receptor 2 (VEGFR2) and has demonstrated activity in patients with recurrent glioblastoma, warranting evaluation of the addition of cabozantinib to radiotherapy (RT) and temozolomide (TMZ) for patients with newly diagnosed high-grade glioma. METHODS Cabozantinib doses of 40 m...

Bladder cancer is a molecular disease driven by the accumulation of genetic, epigenetic, and environmental factors. The aim of this study was to detect the deletions/duplication mutations in TP53 gene exons using multiplex ligation-dependent probe amplification (MLPA) method in the patients with transitional cell carcinoma (TCC). The achieved formalin-fixed paraffin-embedded tissues from 60 pat...

OBJECTIVE Cervical pedicle screw (CPS) placement is very challenging due to high risk of neurovascular complications. We devised a new technique (medial funnel technique) to improve the accuracy and feasibility of CPS placement. METHODS We reviewed 28 consecutive patients undergoing CPS instrumentation using the medial funnel technique. Their mean age was 51.4 years (range, 30-81 years). Preo...

introduction: previous studies indicate that exercise influences cognitive function. nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. the present study aimed to investigate the effects of treadmill exercise on ltp in the dentate gyrus of rats. methods: th...

JERRY J. MAYO, LEN KRAVITZ, AND JATAPORN WONGSATHIKUN. Detecting The Onset Of Added Cardiovascular Strain During Combined Arm And Leg Exercise. JEPonline. 2001;4(3):53-60. The purpose of this study was to determine the preferred distribution of arms to legs during combined arm-leg exercise. Fourteen subjects (7 males, 7 females) completed seven experimental testing sessions: one maximal oxygen ...