The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequencies. Here we explore the mechanisms driving this frequency-dependent role usin...

In addition to the usual retroviral promoter, the mouse mammary tumor virus (MMTV) long terminal repeat carries a second promoter located in the U3 region. Here we show that both of these promoters are independently able to give rise to superantigen activity in transgenic mice. The ability of multiple MMTV promoters to drive superantigen expression underscores its importance in the virus life c...

We compare the energy efficiency of hybrid and fuel cell vehicles as well as conventional internal combustion engines. Our analysis indicates that fuel cell vehicles using hydrogen from fossil fuels offer no significant energy efficiency advantage over hybrid vehicles operating in an urban drive cycle. We conclude that priority should be placed on hybrid vehicles by industry and government.

This paper demonstrates bandwidth requirement for optical DPQSK transmitter using one Dual-drive Mach Zehnder Modulator (DDMZM) for 100Gb/s physical transmission. The result shows that at receiver bandwidth of 40GHz, NRZDQPSK signal requires 60GHz modulation bandwidth at least, while RZ-DQPSK scheme demands less bandwidth, about 40GHz for 50% duty cycle RZ-DQPSK signal.

Aim There is mounting concern that climate change will lead to the collapse of cyclic population dynamics, yet the influence of climate variability on population cycling remains poorly understood. We hypothesized that variability in survival and fecundity, driven by climate variability at different points in the life cycle, scales up from local populations to drive regional characteristics of p...

Comparison between Staggered and Unstaggered Finite-Difference Time-Domain Grids for Few-Cycle Temporal Optical Soliton Propagation L. Gilles,∗,† S. C. Hagness,∗ and L. Vázquez† ∗Department of Electrical and Computer Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, Wisconsin 53706; and †Departamento de Matemática Aplicada, Escuela Superior de Informática, Universidad Compl...

Kinesin is a microtubule-based motor protein that pulls vesicles or organelles towards the plus end of microtubules. Structural changes in the protein that drive motility are coupled to ATP binding and hydrolysis. Here, we attempt to integrate recent structural and kinetic results into a picture of the mechanochemical cycle of kinesin.

the efficiency of induction motors decreases at light loads. efficiency optimizer control systemsadjust the motor flux value to achieve the best efficiency in a wide range of load variations. reduced fluxoperation has some other benefits such as power factor improvement and torque ripple reduction. the latter isan important issue in a direct torque controlled induction motor drive. in this pape...

The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but whether it acts during myelination and repair of demyelinating lesions remains unexplored. Here, we took advantage of a viable Cdk2(-/-) mutant mouse to investigate the function of this cell cyc...

Many types of cells compensate for induced alterations in the length of one cell cycle phase (G1, S, or G2) by altering the lengths of the other phases. Here we show that, when cells in Drosophila wing discs are delayed in G1, they maintain normal division rates by accelerating passage through S and G2. Similarly, when G2-->M progression is retarded, G1-->S progression accelerates. This compens...