BACKGROUND AND PURPOSE Prostaglandin (PG) D(2) has emerged as a key mediator of allergic inflammatory pathologies and, particularly, PGD(2) induces leukotriene (LT) C(4) secretion from eosinophils. Here, we have characterized how PGD(2) signals to induce LTC(4) synthesis in eosinophils. EXPERIMENTAL APPROACH Antagonists and agonists of DP(1) and DP(2) prostanoid receptors were used in a model...

In this paper, we show that VC-minimal ordered fields are real closed. We introduce a notion, strictly between convexly orderable and dp-minimal, that we call dp-small, and show that this is enough to characterize many algebraic theories. For example, dp-small ordered groups are abelian divisible and dp-small ordered fields are real closed.

Dynamic Programming (DP) is an important technique used in solving optimization problems. A close correspondence between DP recurrences and Constraint Handling Rules with rule priorities (CHR) yields natural implementations of DP problems in CHR. In this work, we evaluate different implementation techniques with respect to their runtime. From our results we derive a set of guidelines for implem...

We show basic facts about dp-minimal ordered structures. The main results are: dp-minimal groups are abelian-by-finite-exponent, in a divisible ordered dp-minimal group, any infinite set has non-empty interior, and any theory of pure tree is dp-minimal.

Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD2 cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2...

The main result is the prove of the linearity of the dp-rank. We also prove that the study of theories of finite dp-rank cannot be reduced to the study of its dp-minimal types and discuss the possible relations between dp-rank and VC-density.

OBJECTIVE Somatotropinomae are classified as densely and sparsely granulated adenomae, which typically exhibit a perinuclear pattern (PP) and a dot pattern (DP) in cytokeratin (CK) immunostaining respectively. Some exhibit a mixed pattern (MP). We studied the relationship between these somatotropinoma subtypes and their clinico-pathological features. METHODS The study population consisted of ...

BACKGROUND Few studies have addressed the influence of dietary patterns (DP) during adolescence on the amount of body fat in early adulthood. OBJECTIVE To analyze the associations between DP tracking and changes in the period between 15 and 18 years of age and the percentage of body fat (%BF) at age 18 years. METHODS We used data from 3,823 members of the 1993 Pelotas (Brazil) birth cohort....

TO THE EDITOR Although keratinocytes are the primary constituents of the hair follicle and generate the hair shaft, mesenchymal cells also have important functions. These include the follicular dermal papilla (DP) and the connective tissue sheath or dermal sheath (CTS). The DP is embedded in the hair bulb during the anagen phase and forms a compact ball during the telogen phase, whereas CTS cel...