Transformed lymphocytes exhibit aberrant growth potential resulting from enhanced proliferation and resistance to apoptotic stimuli. These mechanisms also influence the development of autoimmune disease, where dysregulated lymphocyte homeostasis has been implicated in expansion of autoreactive T cells. In the nonobese diabetic (NOD) mouse, a murine model of autoimmune type 1 diabetes and Sjögre...

BACKGROUND Thymus organogenesis and T lymphocyte development are accomplished together during fetal life. Proper development and maintenance of thymus architecture depend on signals generated by a sustained crosstalk between developing thymocytes and stromal elements. Any maturation impairment occurring in either cellular component leads to an aberrant thymic development. Gene expression occurr...

Background—We have previously reported that disseminated pulmonary Mycobacterium avium complex (MAC) infection is more common in human T lymphotrophic virus type I (HTLV-I) carriers than in non-carriers. However, the reason for this remains unclear. It has been shown that glycopeptidelipid (GPL), one of the lipid components of the cell envelope of MAC, is able to reduce the lymphocyte blastogen...

BACKGROUND We have previously reported that disseminated pulmonary Mycobacterium avium complex (MAC) infection is more common in human T lymphotrophic virus type I (HTLV-I) carriers than in non-carriers. However, the reason for this remains unclear. It has been shown that glycopeptidelipid (GPL), one of the lipid components of the cell envelope of MAC, is able to reduce the lymphocyte blastogen...

OBJECTIVES To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1-infected pregnant women. DESIGN Multicenter, randomized, double-blind, controlled trial of different durations of zidovudine prophylaxis. SETTING 27 hospitals in Thailand. PARTICIPAN...

Background: Adenocarcinoma of the prostate is an invasive carcinoma, a neoplasm epithelial cells with secretory cell differentiation. Histomorphology glandular. The are sheets or single neoplasia, basal not seen in this carcinoma. Tumor-Infiltrating Lymphocytes (TILs) lymphocytes that migrate to tumor peritumoral cells. In malignancy, T lymphocyte infiltration can be found, indicating immune re...

Introduction: Helicobacter Pylori (HP) is the most common bacteria that causes chronic bacterial infections in humans. We aimed to investigate possible relationship between HP infection and autoimmune thyroid diseases, as well density platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte (NLR). Methods: A total of 3380 patients who underwent upper gastro intestinal system endoscopy our te...

In this paper, it is assumed that the “Decision Making Units“( ) are consist of positive and negative input and output. Firstly, the optimistic and pessimistic models have been suggested by using negative data and then units with most productive scale size are measured in optimistic and pessimistic models. These productive values are compared with double frontiers and Hurwicz’s Criterion to obt...

INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), C-reactive protein (CRP), ferritin level, CRP-to-albumin (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) non-C...