We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a pro...

BACKGROUND Resorbable bone hemostasis materials, oxidized regenerated cellulose (ORC) and microfibrillar collagen (MFC), remain at the site of application for up to 8 weeks and may impair osteogenesis. Our experimental study compared the effect of a water-soluble alkylene oxide copolymer (AOC) to ORC and MFC versus no hemostatic material on early bone healing. METHODS Two circular 2.7 mm non-...

BACKGROUND AND PURPOSE Experimental studies have suggested a role for iron accumulation in the pathology of TBI. Magnetic field correlation MR imaging is sensitive to the presence of non-heme iron. The aims of this study are to 1) assess the presence, if any, and the extent of iron deposition in the deep gray matter and regional white matter of patients with mTBI by using MFC MR imaging; and 2)...

BACKGROUND AND PURPOSE Deposition of iron has been recognized recently as an important factor of pathophysiologic change including neurodegenerative processes in multiple sclerosis (MS). We propose that there is an excess accumulation of iron in the deep gray matter in patients with MS that can be measured with a newly developed quantitative MR technique--magnetic field correlation (MFC) imagin...

BACKGROUND Osteochondritis dissecans (OCD) of the knee is a disorder in juveniles and young adults; however, its etiology still remains unclear. For OCD at the medial femoral condyle (MFC), it is sometimes observed that the lesion has a connection with fibers of the posterior cruciate ligament (PCL). Although this could be important information related to the etiology of MFC OCD, there is no re...

Abstract Microbial fuel cells (MFCs) are environmentally friendly devices which used to convert chemical energy in organic wastes electrical energy. MFCs have a strong non-linearity that requires very sophisticated controlling system. Consequently, this makes optimization and performance study of difficult process. For better estimation the constants for MFCs, global sensitivity analysis is per...

the lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. unfortunately, a large number of candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. the aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...

Simultaneous anaerobic and aerobic degradation pathways in two-chamber, tubular microbial fuel cells (MFCs) facilitated pentachlorophenol (PCP) mineralization by a mediator-less biocathode. PCP was degraded at a rate of 0.263 ± 0.05 mg/L-h (51.5 mg/g VSS-h) along with power generation of 2.5 ± 0.03 W/m(3). Operating the biocathode MFC at 50°C improved the PCP degradation rate to 0.523 ± 0.08 mg...

A sediment microbial fuel cell (SMFC) is a type of microbial fuel cell (MFC) that has recently attracted significantly attentions due to its unique property of removing organic and inorganic compounds from sediments. In this study the experiments were carried out in a dual-chamber SMFC with external resistances 30 kΩ-50 Ω. The SMFC was produced power about 630 mV with maximum power density 40 m...

Microbial fuel cells (MFCs) are devices that exploit microorganisms as biocatalysts to recover energy from organic matter in the form of electricity. One of the goals of MFC research is to develop the technology for cost-effective wastewater treatment. However, before practical MFC applications are implemented it is important to gain fundamental knowledge about long-term system performance, rep...