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As a glycosphingolipid that can bind to several extracellular matrix proteins, sulfatide has the potential to become an effective targeting agent for tumors overexpressing tenasin-C in their microenvironment. To overcome the dose-limiting toxicity of doxorubicin (DOX), a sulfatide-containing nanoliposome (SCN) encapsulation approach was employed to improve treatment efficacy and reduce side eff...

Curcumin is a plant-derived compound with polypharmacological properties that are hampered by its poor solubility, fast degradation, etc. Wound closure complications follow tooth extraction numerous, and relatively frequently additional treatment needed to prevent unwanted process chronification. The present study aims compare the effects of free nanoliposome-encapsulated curcumin on wound clos...

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Polytene chromosomes from the salivary gland cells of Drosophila third instar larvae have been used extensively for cytological and genetic studies. Polytene chromosomes have also been used to study transcription because an actively transcribing gene is often manifested as a localized region of chromatin decondensation or “puff”. Several methods have been developed to detect sites of active tra...