PURPOSE To develop a deliverable four-dimensional (4D) intensity-modulated radiation therapy (IMRT) planning method for dynamic multileaf collimator (MLC) tumor tracking delivery. METHODS AND MATERIALS The deliverable 4D IMRT planning method involves aligning MLC leaf motion parallel to the major axis of target motion and translating MLC leaf positions by the difference in the target centroid...

Purpose: This study aims to evaluate the treatment plans of Volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation (IMRT) techniques for cervical-thoracic esophageal cancers. Methods and Materials: Sixty patients were retrospectively identified. Several parameters evaluated based on target conformity and dose-volume histograms organs at risk (lung, spinal cord, heart). A ...

PURPOSE/OBJECTIVES The purpose of this study is to describe a novel brachytherapy technique for lip Squamous Cell Carcinoma, utilizing a customized mold with embedded brachytherapy sleeves, which separates the lip from the mandible, and improves dose homogeneity. MATERIALS AND METHODS Seven patients with T2 lip cancer treated with a "sandwich" technique of High Dose Rate (HDR) brachytherapy t...

BACKGROUND In combined proton-carbon fixed-nozzle treatment facilities with raster scanning delivery, the scattering of proton pencil beams caused by nozzle elements and the relatively large nozzle-to-isocenter distance cause a beam broadening. This may pose limitations to the achievable dose conformity. One way to counteract this effect is by delivering the treatment in a position closer to th...

BACKGROUND To evaluate the incidence of chest wall toxicity after lung stereotactic ablative radiotherapy (SABR) and identify risk factors for the development of rib fracture. METHODS Thirty-nine patients with 49 lesions underwent SABR for primary or metastatic lung tumors using Cyberknife® with tumor tracking systems. Patient characteristics, treatment factors and variables obtained from dos...

Purpose: This work evaluates the use of target and organs at risk (OAR) dose-volume goals in 3D conformal radiotherapy (3DCRT) planning for node positive breast cancer (NPBC) patients undergoing regional nodal irradiation after lumpectomy/mastectomy. Methods: Dosimetric data for 262 NPBC patients receiving regional nodal and whole breast/chest wall (WB/CW) irradiation from 2000-2009 were analyz...

Radiation quality indices (QI), tumor control probability (TCP), and normal tissue complication probability(NTCP) were evaluated for ideal single and double plane HDR interstitial implants. In the analysis, geometrically-optimized at volume (GOV) treatment plans were generated for different values of inter-source-spacing (ISS) within the catheter, inter-catheter-spacing (ICS), and inter-plane-s...

UNLABELLED The therapeutic effects of peptide receptor-based radionuclide therapy are extensively being investigated in rats bearing tumors. Both the dose to the tumor and the therapy-limiting dose to normal tissues, such as kidneys and bone marrow, are of interest for these preclinical studies. The aim of this work was to develop a generalized computational model for internal dosimetry in rats...

BACKGROUND To compare intracavitary brachytherapy (ICBT) planning methods for cervical cancer, based on either orthogonal radiographs (conventional plan) or CT sections (CT plan); the comparison focused on target volume coverage and dose volume analysis of organs at risk (OARs), by representing point doses defined by the International Commission on Radiation Units and Measurement (ICRU) and dos...

Information concerning radiation-induced malignancies comes from the A-bomb survivors and from medically exposed individuals, including second cancers in radiation therapy patients. The A-bomb survivors show an excess incidence of carcinomas in tissues such as the gastrointestinal tract, breast, thyroid, and bladder, which is linear with dose up to about 2.5 Sv. There is great uncertainty conce...