PURPOSE This first-in-human dose-escalation trial evaluated the safety, tolerability, maximal-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of pictilisib (GDC-0941), an oral, potent, and selective inhibitor of the class I phosphatidylinositol-3-kinases (PI3K). PATIENTS AND METHODS Sixty patients with solid tumors re...

  Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GIST has been shown to over-express c-KIT (CD117), the receptor tyrosine kinase. Imatinib (STI571 or Glivec) is a new type of tyrosine kinase inhibitor that selectively inhibits various tyrosine kinases and has been successfully used to trea...

Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of systemic extranodal non-Hodgkin diffuse large B-cell lymphoma (DLBCL). We report a rare case of IVLBCL who showed diffuse 18F-fluorodeoxyglucose (FDG) uptake in the lung in FDG-positron emission tomography/computed tomography (PET/CT) without respiratory symptoms or chest CT abnormalities. Serum biochemical studies...

PURPOSE Erlotinib, an orally active selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, has synergistic activity with radiation and with cisplatin. The EGFR is overexpressed in the majority of head and neck cancers. The primary objective of this phase I study was to determine the maximum-tolerated dose (MTD) of erlotinib in combination with low-dose daily cisplat...

results fdg-pet/ct findings showed no evidence of malignant disease. there was diffusely increased fdg in soft tissue around the shoulders and hips and fdg-positive axillary lymph nodes consistent with pmr. background remitting seronegative symmetrical synovitis with pitting edema (rs3pe) is a rare, but well-defined syndrome comprising polyarthritis with symmetrical synovitis of the small joint...

Dose-intensified radiation has been shown to improve tumor control and survival in Stage I NSCLC, III NSCLC radiation-alone studies. However, NRG-RTOG 0617 showed that with concurrent chemo-RT, higher-dose RT paradoxically worsened survival. Here we present the results of a multicenter trial led by NRG Oncology American College Radiology Network (ACRIN), which aimed determine whether adaptive i...

UNLABELLED The aims of this study were to determine whether body weight or body surface area (BSA) should be used for noninvasive measurement of the cerebral metabolic rate of glucose (CMRGlc) by FDG PET with a standardized input function (SIF) and an autoradiographic method and to validate the procedure in a large population from different PET centers. METHODS Plasma input functions measured...

UNLABELLED The recovery of function in myocardium defined as viable by (18)F-FDG PET may differ from that defined by dobutamine stress echocardiography (DSE). The aim of this study was to investigate the difference in the oxidative metabolic response between myocardial segments with preserved contractile reserve (CR) and those without CR, in segments with and without preserved glucose metabolis...

BACKGROUND 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/ computed tomography (CT) imaging demands guidelines to safeguard sufficient image quality at low radiation exposure. Various FDG dose regimes have been investigated; however, body weight-adapted dose regimens and related image quality (IQ) have not yet been compared in the same patient. PURPOSE To investigate ...

intravascular large b-cell lymphoma (ivlbcl) is a rare and aggressive subtype of systemic extranodal non-hodgkin diffuse large b-cell lymphoma (dlbcl). we report a rare case of ivlbcl who showed diffuse 18f-fluorodeoxyglucose (fdg) uptake in the lung in fdg-positron emission tomography/computed tomography (pet/ct) without respiratory symptoms or chest ct abnormalities. serum biochemical studies...