The development of novel, systemically administered radionuclide therapies (such as radioimmunotherapy) relies on the ability to predict dose-limiting toxicity to normal tissue. Where the kidney is the principal route of excretion of the radionuclide preparation and/or breakdown of products, nephrotoxicity may be the dose-limiting factor. Until recently, conventional (MIRD) dosimetry assumed th...

radiotherapy dose calculations can be evaluated by monte carlo (mc) simulations with acceptable accuracy for dose prediction in complicated treatment plans. in this work, standard, livermore and penelope electromagnetic (em) physics packages of geant4 application for tomographic emission (gate) 6.1 were compared versus monte carlo n-particle extended (mcnpx) 2.6 in simulation of 6 mv photon lin...

The gamma tool was developed to quantitatively compare dose distributions, either measured or calculated. Before computing gamma, the dose and distance scales of the two distributions, referred to as evaluated and reference, are renormalized by dose and distance criteria, respectively. The renormalization allows the dose distribution comparison to be conducted simultaneously along dose and dist...

Introduction: Development of a novel radiopharmaceutical needs assessment of its biological- distribution in animal models, most commonly mice prior to its common application. This study describes the biodistribution and absorbed dose prediction 131I-MIBG in human organs after injection in mice.   Materials and Methods: In this research, 131I-MIBG radiopha...

background: gold nanoparticles (gnps) have been shown as a good radiosensitizer. in combination with radiotherapy, several studies with orthovoltage x-rays have shown considerable dose enhancement effects. this paper reports the dose enhancement factor (def) due to gnps in 18 megavoltage (mv) beams. materials and methods: different geometrical 50-nm gnps configurations at a concentration of 5 m...

Introduction: 192Ir is one of the important sources frequently used in brachytherapy. Up to now, a lot of commercial models of this source have been made which Ir-192 has been recently added to them. The aim of the present study is to determine the dosimetric parameters of this new source model based on the recommendations of TG-43(U1) protocol using Monte Carlo simulation tech...

Background: Monte Carlo determination of TG-43 brachytherapy dosimetry parameters and dose distribution calculation for 131Cs source model CS-1 are presented in this study. Materials and Methods: The dose distribution was calculated around the 131Cs Model CS-1 located in the center of 30 cm ×30 cm ×30 cm water, and soft tissue phantoms cube using MCNP code by Monte Carlo method. The percentage ...