The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and cr...

Amikacin, a new semisynthetic aminoglycoside antibiotic, was administered parenterally to 20 patients suffering from severe Gram-negative bacterial infections. The antibiotic was found to be highly effective in controlling infection. It was well tolerated and no signs of nephro- or otoxicity were observed. The few side-effects which were seen appeared to be dose-related. The recommended 12-hour...

Content organisation Cardio toxic effect of chemotherapy is a well-recognised problem in cancer patients. Cardio toxicity depends on multiple predisposing factors, specific components of the chemotherapy regimen, length of treatment, and dosage. We will present the spectrum of most common cardiotoxic chemotherapy agents and their combinations, specific effects on the myocardium, and imaging fea...

Because of the high therapeutic potential of paclitaxel (Taxol) and doxorubicin (Adriamycin) in women with breast cancer, a series of studies evaluating the combination of the two drugs have been undertaken at the National Cancer Institute in Milan, Italy. Investigations aimed at establishing the optimal dosage regimen to maximize the combination’s therapeutic effectiveness and to minimize the ...

BACKGROUND The standard caspofungin treatment regimen (50 mg/day after a 70-mg dose on day 1) is effective and well tolerated for the treatment of invasive candidiasis, but experience with higher doses of caspofungin is limited. We evaluated the safety and efficacy of caspofungin at 3 times the standard dosing regimen. METHODS Patients with proven invasive candidiasis were randomized to recei...

BACKGROUND This study analyzed regularity in the daily dosage of antidepressants taken by patients with bipolar disorder and identified the factors associated with irregularity. METHODS Daily self-reported medication dosage taken and mood ratings were available from 144 patients who received treatment as usual. All 144 patients took the same antidepressant for at least 100 days. One hundred e...

BACKGROUND Pretibial myxedema (PTM) is an uncommon dermopathy associated with autoimmune thyroid diseases. Now it is thought to be autoimmune and its treatment with glucocorticoid is helpful. However, it has not been evaluated. METHODS A prospective randomized controlled trial was performed in 110 patients with PTM to evaluate the efficacy and safety of triamcinolone acetonide with intralesio...

Anti-TB drugs for children: Aetiotropic therapy is used the treatment of tuberculosis (TB) in children, as well adult patients. Anti-tuberculosis (anti-TB drugs) are divided into 3 lines, taking account drug sensitivity Mycobacterium (MBT). First-line anti-TBdrugs (basic) to treat TB caused by drug-susceptible MBT. Second- and third-line (reserve) recommended MBT-induced multidrug-resistant (MD...