Background: Low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP), has recently been linked to obesity, insulin resistance syndromes such as polycystic ovary syndrome (PCOS), and an increased risk of cardiovascular disease. Because the insulin sensitizer metformin has been shown to improve metabolic disturbances in PCOS, it was of particular interest to ...

OBJECTIVE Cerebral vasospasm is a common and potentially devastating complication of aneurysmal subarachnoid hemorrhage (aSAH). Inflammatory processes seem to play a major role in the pathogenesis of vasospasm. C-reactive protein (CRP) constitutes a highly sensitive inflammatory marker. Elevation of serum CRP levels has been demonstrated in patients with aSAH. The purpose of the current study w...

Methods Group 1 (36 patients) received the combined therapy by glucocorticoids (Pr) and methotrexate (MTX). Cyclophosphamide (CYC) used at 2 patients as first therapy with widespread inflammation and in 6 – at inefficiency of primary treatment of MTX (group 2). In 5 children with refractory TA – infliximab (INF) (group 3). TR efficacy was estimated by TA activity index (AI), based on Birmingham...

Background Objective: To evaluate the utility of specific cut-off values for C- reactive protein (CRP) and immature-to-total neutrophil ratio (I/T) as screening tests for meningitis in culture negative early onset sepsis (EOS). Materials and Methods Retrospective chart review of 97 newborns with culture negative sepsis who had lumbar puncture performed as part of the sepsis evaluation in a l...

Introduction: The effect of statins in reducing the risk of acute cardiovascular events is not only due to their effect on serum cholesterol level but also from their anti-inflammatory effects, particularly those resulting from reducing of C - reactive protein (CRP), is important. Atorvastatin dose and duration of treatment display different effects. This study compared the effects of high and ...

Objective(s) Homocysteine, hs-CRP and fibrinogen are three novel cardiovascular risk factors. The aim of this study was to examine the effect of a single bout of circuit resistance exercise on homocysteine, hs-CRP and fibrinogen levels in healthy and inactive men. Materials and Methods The subjects were randomly divided into the experimental group (n= 14) and the control group (n= 9). Circui...

Objective(s) In the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. In this study, we aimed to investigate the value of procalcitonin, and C- reactive protein in establishing the diagnosis of neonatal sepsis. Materials and Methods Blood samples were collected at admission from 69 neonates with suspected infection (admi...