نتایج جستجو برای: dopaminergic neurons da

تعداد نتایج: 523915  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Kechun Yang Lori Buhlman Ghous M Khan Robert A Nichols Guozhang Jin J Michael McIntosh Paul Whiteaker Ronald J Lukas Jie Wu

Diverse nicotinic acetylcholine receptor (nAChR) subtypes containing different subunit combinations can be placed on nerve terminals or soma/dendrites in the ventral tegmental area (VTA). nAChR α6 subunit message is abundant in the VTA, but α6*-nAChR cellular localization, function, pharmacology, and roles in cholinergic modulation of dopaminergic (DA) neurons within the VTA are not well unders...

Journal: :Developmental neurobiology 2015
Qiaoqiao Yang Shuxi Liu Min Yin Yanqing Yin Guomin Zhou Jiawei Zhou

Dopaminergic (DA) neurons in the midbrain ventral periaqueductal gray matter (PAG) play critical roles in various physiological and pathophysiological processes including sleep-wake rhyme, antinociception, and drug addiction. However, the molecular mechanisms underlying their development are poorly understood. Here, we showed that PAG DA neurons arose as early as E15.5 in mouse embryos. During ...

Journal: :Journal of neurophysiology 2011
Takashi Tateno Hugh P C Robinson

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are expressed in dopaminergic (DA) neurons of the ventral tegmental area (VTA) as well as in DA and GABAergic neurons of the substantia nigra (SN). The excitation of DA neurons induced by ethanol has been proposed to result from its enhancing HCN channel current, I(h). Using perforated patch-clamp recordings in rat midbrain ...

2012
Sareh Kazmi Laya Kafami Ahmad Ebrahimi Mohammad Taghi Joghataei

arkinson’s disease (PD) is one of the most common neurodegenerative diseases characterized by tremor, stiffness and slowness of motion due to dopamine (DA) depletion following dramatic loss of dopaminergic neurons in Substantia nigra. Unfortunately, this debilitating disease has no curative treatment. Neuroprotective agents might be useful via postponing the initiation of neurodegenerative proc...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
David Fan Mark A Rossi Henry H Yin

The timing of actions is critical for adaptive behavior. In this study we measured neural activity in the substantia nigra as mice learned to change their action duration to earn food rewards. We observed dramatic changes in single unit activity during learning: both dopaminergic and GABAergic neurons changed their activity in relation to behavior to reflect the learned instrumental contingency...

Journal: :Cell cycle 2011
Shane Grealish Johan Jakobsson Malin Parmar

A series of recent publications have shown that human fibroblasts can be directly converted to functional neurons using defined combinations of transcription factors. The resulting neurons are called induced neurons (iN). When compared with induced pluripotent stem (iPS) cell technology, where somatic cells can be reprogrammed to neurons via a pluripotent stem cell state, lineage reprogramming ...

Journal: :The Journal of clinical investigation 2014
Guoxiang Liu Jia Yu Jinhui Ding Chengsong Xie Lixin Sun Iakov Rudenko Wang Zheng Namratha Sastry Jing Luo Gay Rudow Juan C Troncoso Huaibin Cai

Subpopulations of dopaminergic (DA) neurons within the substantia nigra pars compacta (SNpc) display a differential vulnerability to loss in Parkinson's disease (PD); however, it is not clear why these subsets are preferentially selected in PD-associated neurodegeneration. In rodent SNpc, DA neurons can be divided into two subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
M J Millan A Gobert A Newman-Tancredi F Lejeune D Cussac J M Rivet V Audinot T Dubuffet G Lavielle

The benzopyranopyrrole S33084 displayed pronounced affinity (pK(i) = 9.6) for cloned human hD(3)-receptors, and >100-fold lower affinity for hD(2) and all other receptors (>30) examined. S33084 concentration dependently, potently, and competitively (pA(2) = 9.7) antagonized dopamine (DA)-induced [(35)S]guanosine-5'- O-(3-thio)triphosphate (GTPgammaS) binding at hD(3)-receptors. It also concentr...

Journal: :Human molecular genetics 2015
Guoxiang Liu Carmelo Sgobio Xinglong Gu Lixin Sun Xian Lin Jia Yu Loukia Parisiadou Chengsong Xie Namratha Sastry Jinhui Ding Kelly M Lohr Gary W Miller Yolanda Mateo David M Lovinger Huaibin Cai

Preferential dysfunction/degeneration of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main movement symptoms manifested in Parkinson's disease (PD). Although the Leucine-rich repeat kinase 2 (LRRK2) G2019S missense mutation (LRRK2 G2019S) is the most common causative genetic factor linked to PD, the effects of LRRK2 G2019S on the function and survi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Alicia M Pickrell Milena Pinto Aline Hida Carlos T Moraes

Parkinson's disease (PD) is one of the most common progressive neurodegenerative disorders, characterized by resting tremor, rigidity, bradykinesia, and postural instability. These symptoms are associated with massive loss of tyrosine hydroxylase-positive neurons in the substantia nigra (SN) causing an estimated 70-80% depletion of dopamine (DA) in the striatum, where their projections are loca...

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