نتایج جستجو برای: dopamine agonists

تعداد نتایج: 83065  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
R Andretic J Hirsh

We investigated the circadian function of Drosophila dopamine receptors by using a behaviorally active decapitated preparation that allows for direct application of drugs to the nerve cord. Quinpirole, a D2-like dopamine receptor agonist, induces reflexive locomotion in decapitated flies. We show that the amount of locomotion induced changes as a function of the time of day, with the highest re...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Takato Hiranita Stephen J Kohut Paul L Soto Gianluigi Tanda Theresa A Kopajtic Jonathan L Katz

Atypical dopamine-uptake inhibitors have low abuse potential and may serve as leads for development of cocaine-abuse treatments. Among them, the benztropine (BZT) derivatives, N-butyl (JHW007), N-allyl (AHN2-005), and N-methyl (AHN1-055) analogs of 3α-[bis(4'-fluorophenyl)methoxy]-tropane dose-dependently decreased cocaine self-administration without effects on food-maintained responding. Our s...

Journal: :The Journal of clinical endocrinology and metabolism 1992
J L Cameron S M Pomerantz L M Layden J A Amico

Administration of the dopamine receptor agonist apomorphine causes a dose-dependent increase in plasma oxytocin concentrations and dose-specific behavioral changes in rodents. To investigate whether dopamine receptor agonists will elicit similar neuroendocrine and behavioral effects in primates, we administered graded doses of apomorphine and the respective dopamine D1 and D2 receptor agonists,...

Journal: :The Journal of Clinical Endocrinology & Metabolism 2010

Journal: :The Journal of pharmacology and experimental therapeutics 1998
L Pulvirenti C Balducci M Piercy G F Koob

Dopamine neurotransmission is an important neuropharmacological component of cocaine self-administration in rodents. Terguride is a prototype drug belonging to a recently characterized class of compounds, dopamine partial agonists, which appear to possess a unique pharmacological profile in altering dopamine neurotransmission, where these drugs act as antagonists in conditions of high dopaminer...

Journal: :Pharmacological reports : PR 2011
Alessandra Fanciulli Roberta Misasi Dario Campanelli Francesca R Buttarelli Francesco R Pontieri

The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering Parkinson's disease. An 8-week in vivo exposure to pramipexole (0.7 mg free base, 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluoresce...

Journal: :The Cochrane database of systematic reviews 2011
Hanna Scholz Claudia Trenkwalder Ralf Kohnen Dieter Riemann Levente Kriston Magdolna Hornyak

BACKGROUND According to clinical guidelines, dopamine agonists are the first-line treatment of restless legs syndrome (RLS). OBJECTIVES To evaluate efficacy and safety of dopamine agonists for RLS. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library 2008, Issue 4), MEDLINE, EMBASE, PsycINFO and CINAHL, from January 1985 to December 2008, plus...

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