نتایج جستجو برای: dnmts
تعداد نتایج: 359 فیلتر نتایج به سال:
Alzheimer's disease (AD) is a common neurodegenerative disease resulting in progressive dementia, and is a principal cause of dementia among older adults. Folate acts through one-carbon metabolism to support the methylation of multiple substrates. We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid β-peptide (Aβ) production in AD...
DNA methylation is a fundamental feature of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantage. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. By focusing on interactions existing between DNMT3A and DNMT3A-binding protein (D3A-BP), our work identifies the DNMT3A/ISGF3γ interaction such as a biomarke...
Background: Development of cloned bovine embryos. Materials and Methods: Oocytes collection,oocyte denudation, oocyte enucleation, nuclear transfer, electrofusion, reconstructed embryo activation, culture of reconstructed and IVF embryo,and treatment with SAH post fusion interval Treatment of reconstructed embryos with TSA for 12 hours after activation, preparation of somatic donor cells, donor...
Background: Recurrent high grade serous ovarian cancer (HGSOC) is incurable and lethal. Therefore, novel drug combinations are critically needed for this patient population. DNA methyltransferase inhibitors (DNMTi) can cause damage, which activates poly(ADP-ribose) polymerase (PARP) leads to PARP trapping. Additionally, DNMTi incorporated into replicating DNA, causes DNMT-DNA adducts that then ...
Prostate cancer is the leading cause of cancer related death in most developed countries, and is the most common malignancy in males. Early detection of prostate cancer, multiple biopsies, and improved treatment currently represent the most critical strategies to decrease prostate cancer mortality. The development of prostate cancer is a multi-step process through a series of morphologically di...
DNA methylation was reported as a possible stress-adaptation mechanism involved in the transcriptional regulation of stress responsive genes. Limited data are available on effects of psychological stress and early-life nutritional stress on DNA methylation regulators [DNMTs: DNA (cytosine-5)-methyltransferase 1 (DNMT1), DNMT1 associated protein (DMAP1), DNMT 3 alpha (DNMT3A) and beta (DNMT3B)] ...
Malignant mesothelioma (MM) is one of the worst cancers in terms of clinical outcome, urging the need to establish and characterize new preclinical tools for investigation of the tumorigenic process, improvement of early diagnosis and evaluation of new therapeutic strategies. For these purposes, we characterized a collection of 27 cell lines established from F344 rats, after 136 to 415 days of ...
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