The human MDR1 gene encodes for a P-glycoprotein (PGP), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. The G2677T/A polymorphism in exon 21 is associated with PGP expression and function in humans. The present study was aimed to determine the frequencies of this polymorphism in a healthy po...

BACKGROUND The dialysate of patients on peritoneal dialysis (PD) is used to determine the concentration of growth factors and cytokines, and as a source of resident peritoneal cells for subsequent culture experiments. We hypothesized that the cells contained in spent dialysate samples obtained at the time of the peritoneal equilibration test (PET) and subsequently stored may represent a source ...

Background: Rheumatoid arthritis (RA) is a common autoimmune disease in which combination of risk alleles from different susceptibility genes predisposes the patients to develop clinical symptoms following exposure environmental factors. RA chronic and progressive characterized by synovial inflammation that results destruction affected joints severe problems individual’s mobility. Several immun...

Purpose : It has been known that breast milk cause prolonged unconjugated hyperbilirubinemia. UGT1A1 is a important gene of uridine diphosphate glucuronosyltransferase (UGT) which has a major role of bilirubin metabolism. These findings suggest that there is a relationship between UGT1A1 gene mutation and prolonged jaundice of breast feeding infant. The aim of study was to investigate whether a...

objective(s) the sst-i polymorphic site on the 3' untranslated region of the apo ciii gene, has been previously reported to be associated with hypertriglyceridemia. the aim of the present study was to explore the association between sst-i polymorphism with plasma lipid and lipoprotein levels in hyperlipidemic (hlp) patients from semnan province, iran. materials and methods genomic dna was ...

placental lactogen is a polypeptide hormone that is produced by the placenta, also known as chorionic somatomammotropin hormone. it has both growth hormone and prolactin activities on growth, lactation, and luteal steroid production. the objective of this study was to investigate the bovine placental lactogen (bpl) gene polymorphism of holstein cows in razavi khorasan province. blood samples we...

ameloblastic carcinoma (ac) is a rare malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumor. it may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. epidemiological evidence shows that human cancer is generally caused...

BACKGROUND Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DNA proportion in maternal plasma is relatively consistent as determined using polymorphic genetic markers across different chromosomes in euploid pregnancies. For aneuploid pregnancies, the observed fetal DNA proportion measured using polymorphic genetic markers for the aneuploid chromo...