Screening with dynamic mass redistribution (DMR) assays in a native cell line HT-29 led to identification of two novel series of chemical compounds, 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives, as GPR35 agonists. Of these, 2-(3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile (YE120) and 6-bromo-3-methylthieno[3...

Background Degenerative Mitral Valve Regurgitation (DMR) is a severe form of mitral valve disease for which the survival rate is poor if left untreated. Defining the optimal timing for surgery is challenging in spite of advances in diagnostic imaging. No sensitive measure of left ventricular dysfunction from CMR have yet been reported since the ejection fraction (EF) is usually preserved in DMR...

The COsmic Background Explorer (COBE) satellite, and the Differential Microwave Radiometer (DMR) experiment in particular, was extraordinarily successful. However, the DMR results were announced about 7 years ago, during which time a great deal more has been learned about anisotropies in the Cosmic Microwave Background (CMB). We assess the current state of knowledge, and discuss where we might ...

Abstract There is evidence for the beneficial effects of forage peanut on nutritive value and fermentation profile silages; however, its sugarcane silage have not been determined. The objective study was to evaluate chemical composition, profile, microbial dry matter recovery (DMR) containing various amounts (Arachis pintoi cv. Belmonte) (0%, 25%, 50%, 75% a fresh basis), treated or untreated w...

This paper considers functional central limit theorems for stationary absolutely regular mixing processes. Bounds for the entropy with bracketing are derived using recent results in Nickl and Pötscher (2007). More specifically, their bracketing metric entropy bounds are extended to a norm defined in Doukhan, Massart and Rio (1995, henceforth DMR) that depends both on the marginal distribution o...

BACKGROUND/AIMS Our previous study has demonstrated that down-regulation of miR-376a might contribute to the development of hepatocellular carcinoma (HCC), but the mechanism underlying this down-regulation remains obscure. METHODS/RESULTS histone deacetylase (HDAC) inhibitor increased the level of miR-376a in L02 and Huh7 cells by up-regulating the acetylation level of histone 3 at the Matern...

Loss of imprinting (LOI) is a common epigenetic event in cancer and may serve as an early biomarker in some cancers. To obtain a better understanding of LOI, we studied 41 bladder tumors and their adjacent normal bladder mucosa. We found 2/9 (22.2%) cases that displayed LOI of IGF2 and 2/16 (12.5%) that had LOI of H19, as determined by the evaluation of mRNA for biallelic expression. In additio...

The two-year C OBE-DMR 53 and 90 GHz sky maps, in both galactic and ecliptic coordinates, are used to determine the normalisation of innationary universe models with a at global geometry and adiabatic density perturbations. The appropriately normalised cold and mixed dark matter models and cosmological constant dominated, cold dark matter models, computed for a range of values of b and h, are t...