STUDY QUESTION Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function? SUMMARY ANSWER In vitro MPA treatment suppressed expression of CD40 and CD80 by human primary DCs responding to Toll-like receptor 3 (TLR3) agonist stimulation (i.e. DC activation). Moreover, this MPA-mediated decrease in CD40 expression impaired DC capacity to stimulate T cell prol...

Hormonally induced azoospermia induced by weekly im injections of testosterone enanthate provides effective and reversible male contraception, but more practical regimens are needed. Given our previous findings that six 200-mg pellets implanted subdermally produced more stable, physiological T levels and reduced the delivered T dose by more than 50% while maintaining equally effective suppressi...

INTRODUCTION CYP2C19 and P2Y12 polymorphisms have been claimed to alter the pharmacodynamic response to clopidogrel. ABCB1 polymorphism has been associated with the efflux of clopidogrel resulting in decreased bioavailability. Due to paucity of data from Indian population, the present study was undertaken to evaluate the association of genetic polymorphisms of CYP2C19, P2Y12, and ABCB1 with inh...

s and Reports 285 governments to subsidize or promote actaneously to higher cost, poorer health, tivities providing substantial externaliand less equity. To do this requires that ties-instances in which the patient bengovernments concern themselves less with efits but others do also. The control of providing health care and far more with communicable diseases such as tubercuregulating providers...

Ochrobactrum anthropi is a gram-negative rod of low virulence. Infections due to this organism are uncommon; however in immunocompromised hosts it can cause severe infections. Among the many infections it can cause, infective endocarditis is very rare. Even rarer is infective endocarditis of the native valves, as Ochrobactrum antropi affects damaged or prosthetic valves almost exclusively. This...

Linear and star-shaped, hydroxy-terminated polyethylene glycol (PEG) and 1,3-trimethylene carbonate (TMC)-based oligomers were functionalized by esterification with fumaric acid monoethyl ester (FAME) in the presence of N,N-dicyclohexyl carbodiimide (DCC) and 4dimethylamino pyridine (DMAP) at room temperature. Networks, designed to release only nontoxic degradation products, were obtained by UV...

In 1987, the threat of litigation led to the withdrawal of intrauterine devices (IUDs)from the American market where depot medroxyprogesterone acetate (DMPA)had already been banned. There were fears of repercussions that would have led to the limiting of contraceptive choice in Britain. HIV was also an emerging issue and a revival of interest in barrier contraception led to an emphasis on male ...