Truly environmentally friendly means of detoxifying chemical warfare agents have yet to be developed. Toward this end, Soman (GD), VX and agent simulants were treated with aqueous aluminum sulfate (alum), sodium aluminate, or mixtures of the two. The mixtures were prepared by combining varying volumes of the aqueous salts to give buffered solutions (pH 2-12). Reactions were tracked using phosph...

This document presents the results of numerical analyses SAW gas sensor in steady state. The effect velocity changes depending on how surface electrical conductivity sensing layer is predicted. roughness above piezoelectric waveguide depends profile diffused molecule concentration inside layer. Numerical for DMMP (CAS Number 756-79-6) (RR)-P3HT state are shown. main aim investigations was to...

Two conserved catalytic arginines, Arg-173 and Arg-292, of the tyrosine site-specific recombinase Cre are essential for the transesterification steps of strand cleavage and joining in native DNA substrates containing scissile phosphate groups. The active site tyrosine (Tyr-324) provides the nucleophile for the cleavage reaction, and forms a covalent 3'-phosphotyrosyl intermediate. The 5'-hydrox...

Methylphosphonate (MPn) metabolism has been proposed to be an aerobic source of methane in surface oceanic waters. Previous work by Daniela del Valle, C-MORE post-doctoral fellow in the laboratory of Prof. David Karl, has shown that even though microbes are able produce methane from dissolved MPn in the ocean, this process is not a significant source of methane at Station ALOHA. However, this w...

The toxicity for analogues of sarin (GB), soman (GD), and VX was evaluated using Hydra attenuata as a model organism. The organophosphate nerve agent analogue simulants used in this investigation included the following: isopropyl p-nitrophenyl methylphosphonate (for GB); pinacolyl p-nitrophenyl methylphosphonate (for GD); and diisopropyl S-(2-diisopropylaminoethyl)phosphorothioate, diethyl S-(2...

Paraoxonase 1 (PON1) is a calcium-dependent hydrolase associated with serum high-density lipoprotein particles. PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the active site. Most OPs are hydrolyzed inefficiently. This project seeks to identify nucleophiles that can enhance PON1-mediated OP degradation. A s...

Eight new barium methylphosphonates were prepared and described. In dependence on pH, either barium hydrogen methylphosphonates or barium methylphosphonates can be formed. In the case of barium methylphosphonates, BaCH3PO3·3H2O crystallizes from the solution at room temperature and BaCH3PO3·H2O at a temperature above 65 °C. On heating, these hydrates form two anhydrous barium methylphosphonates...

A methylphosphonate derivative of BrdUrd3 is an inhibitor of the cellular uptake of 5F[6-3H]dUnd and other nucleosides (19). BrdUnd-OPO2Me also produces a delayed inhibitory effect on the growth of culture cells (18). The preparation and chemical properties of BrdUrd-OPO2Me have been re ported (18); the methylphosphonate ester linkage is not attacked by the phosphomonoesterases (8). Membrane tr...