نتایج جستجو برای: dlbcl lymphoma

تعداد نتایج: 102737  

2017
Hina J. Shah Abhishek R. Keraliya Jyothi P. Jagannathan Sree Harsha Tirumani Vikram R. Lele Pamela J. DiPiro

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma. As treatments continues to evolve, so do imaging strategies, and positron emission tomography (PET) has emerged as the most important imaging tool to guide oncologists in the diagnosis, staging, response assessment, relapse/recurrence detection,and therapeutic decision making of DLBCL. Other...

Journal: :Anticancer research 2015
Do Hyoung Lim Won Seog Kim Seok Jin Kim Hae Yong Yoo Young Hyeh Ko

AIM The purpose of the present study was to compare microarray gene-expression profiling data between primary central nervous system (CNS) lymphoma and non-CNS lymphomas. MATERIALS AND METHODS We performed whole-genomic cDNA-mediated annealing, selection and ligation assay with 177 formalin-fixed paraffin-embedded tumor samples. RESULTS We identified 20 differentially expressed genes out of...

Journal: :International journal of clinical and experimental pathology 2015
Ji Chen Xiaoli Feng Mei Dong

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is a rare subtype of non-Hodgkin's lymphoma (NHL) with distinct morphologic and immunohistochemical features. We reported a 57-year-old female with ALK-positive DLBCL in her left nasal cavity. Histologically, the tumor cells were characterized by plasmablastic morphology and tested positive for ALK in a cytoplasmic ...

2015
Xianping Shi Xiaoying Lan Xin Chen Chong Zhao Xiaofen Li Shouting Liu Hongbiao Huang Ningning Liu Dan Zang Yuning Liao Peiquan Zhang Xuejun Wang Jinbao Liu

Resistance to chemotherapy is a great challenge to improving the survival of patients with diffuse large B-cell lymphoma (DLBCL), especially those with activated B-cell-like DLBCL (ABC-DLBCL). Therefore it is urgent to search for novel agents for the treatment of DLBCL. Gambogic acid (GA), a small molecule derived from Chinese herb gamboges, has been approved for Phase II clinical trial for can...

2014
Eun Ju Lee Ki Hoon Ahn Soon Cheol Hong Eun Hee Lee Yong Park Byung Soo Kim

Lymphoma, especially non-Hodgkin's lymphoma is extremely rare in pregnancy. A 24-year-old pregnant woman was diagnosed with diffuse large B-cell lymphoma (DLBCL), a subgroup of non-Hodgkin's lymphoma, at 24 weeks' gestation, and was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. After 4 cycles of R-CHOP, she delivered a healthy baby via...

2005
Chan-Kum Park Young-Ha Oh

p63 is a recently described p53 homologue. It is involved in survival and differentiation of reserve/stem cells in epithelia. To obtain new insights into the role of p63 in malignant lymphomas (MLs), immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs. p63 was expressed in 38 cases of MLs (30.2%) including 32/61 cases (52.5%) of diffuse large B-cell lymphoma (DLBCL), ...

2017
Afshin Beheshti Charles Vanderburg J. Tyson McDonald Charusheila Ramkumar Tatenda Kadungure Hong Zhang Ronald B. Gartenhaus Andrew M. Evens

Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age. The molecular etiology of this remains largely unknown, which impacts the effectiveness of treatment for patients. We proposed that age-dependent circulating microRNA (miRNA) signatures in the host influence diffuse large B cell lymphoma (DL...

2009
Charles H Lawrie Jianxiang Chi Stephen Taylor Daniela Tramonti Erica Ballabio Stefano Palazzo Nigel J Saunders Francesco Pezzella Jacqueline Boultwood James S Wainscoat Christian S R Hatton

MicroRNAs are naturally occurring small RNA species that regulate gene expression and are frequently abnormally expressed in cancers. However, the role of microRNAs in lymphoma is poorly understood. Therefore, we undertook a comprehensive study of microRNA expression in two of the most common lymphomas: diffuse large B-cell lymphoma (DLBCL) (n = 80) and follicular lymphoma (FCL) (n = 18) using ...

2014
Harumi Kato Kennosuke Karube Kazuhito Yamamoto Jun Takizawa Shinobu Tsuzuki Yasushi Yatabe Teru Kanda Miyuki Katayama Yukiyasu Ozawa Kenji Ishitsuka Masataka Okamoto Tomohiro Kinoshita Koichi Ohshima Shigeo Nakamura Yasuo Morishima Masao Seto

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly (EBV[+]DLBCL-E) is classified as a subtype of DLBCL. Until now, its molecular pathogenesis has remained unknown. To identify pathways characteristic of EBV(+)DLBCL-E, gene expression profiling of five EBV(+)DLBCL-E and seven EBV-negative DLBCL (EBV[-]DLBCL) cases was undertaken using human oligonucleotide mic...

2016
Elham Vali Betts Hooman H Rashidi

Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B-lymphocytes with a diffuse growth pattern. The neoplastic cells express B-cell markers such as CD20 and PAX-5 and there may be coexpression of BCL-2, BCL-6, CD10, and MUM-1. With the exception of CD5, other T-cell markers are not commonly expressed in this neoplasm. Here, we describe the first reported case of a DLBCL with abnormal ...

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