A.H. received support from the Alberta Diabetes Institute and the Women & Children’s Health Research Institute at University of Alberta. These Clinical Practice Guideline are endorsed by the Lawson Wilkins Pediatric Endocrine Society. They were developed to be of assistance to endocrinologists by providing guidance and yperglycemic hyperosmolar syndrome (HHS), characterized by extreme elevation...

The interrelationships of L-ascorbic acid (AsA) and dehydro-L-ascorbic acid (DHA) have been investigated both in viva and in vitro by numerous workers, with especial emphasis upon the conversion of DHA to AsA by the animal body (l-8). The conversion of DHA to diketo-L-gulonic acid (DKA) in vitro has been shown by Herbert and coworkers (3), by Borsook (l), and by Penney and Zilva (6), and this c...

BACKGROUND AND OBJECTIVE Diabetic ketoacidosis (DKA) is the most severe acute metabolic complication of type 1 diabetes mellitus. Insulin treatment is commonly guided by plasma glucose levels and changes in venous blood gases, while β-hydroxibutyrate (BHB) levels are rarely measured. The study objective was to evaluate the value of capillary BHB monitoring in the course and resolution of DKA. ...

d iabetic ketoacidosis (DKA) is one of the most common complications in adolescents and young adults with type 1 diabetes. Type 1 diabetes with childhood onset has an incidence that fluctuates from 0.1 to 57.6 per 100,000 and is on the rise (1). In children with type 1 diabetes, the incidence of DKA has been reported to be >30% (2). In a study conducted by Dabelea et al. (3), a higher prevalenc...

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have become increasingly prescribed because of their proven protective effects on the heart and kidneys, carbohydrate-restricted diets are popular therapeutic approaches for patients with obesity diabetes. A 28-year-old obese woman recently diagnosed diabetes developed euglycemic diabetic ketoacidosis (DKA) while dapagliflozin, an SGLT2 inhibito...

BACKGROUND Glycosylated haemoglobin (HbA1c) and random blood glucose are markers of chronic and acute hyperglycaemia respectively. OBJECTIVE We compared HbA1c levels in ketoacidosis (DKA) occurring in known and newly diagnosed diabetes. METHODS Retrospective review of medical records for 83 DKA admissions in 2008 and 2009 with results for HbA1c at presentation. RESULTS There were 52 and 3...

In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. In children with DKA, cerebral edema most often presents with clinical symptoms...

AIM To assess the clinical features, length of stay, incidence rate, mortality, and hospital admissions of patients with episodes of diabetic ketoacidosis (DKA). PATIENTS It was conducted retrospective, cross-sectional study of 164 consecutive admissions of adult patients (2008-August 2012), with type 1 or type 2 diabetes already known or new onset. RESULTS Mortality rate was 1.2%. The DKA ...

To assess the management of diabetic ketoacidosis (DKA) and evaluate if introduction of a critical pathway improves management, we studied adults admitted with DKA to the Medicine and Critical Care Services in a US teaching hospital. Patients admitted with DKA in 1997 before implementation of the critical pathway were the control group (n=72). In 1998, housestaff and nurses in the emergency dep...

BACKGROUND Second generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation linked to the use of SGAs. The aims of this article are to present patients with a history of psychotic disorders and of severe metabolic diabetic ketoacidosis, possibly associated with the use ...