•Expedient assembly of the conidiogenone core via nitrile-assisted TMM diyl cycloaddition•Regio- and diastereoselective decorations D-ring scaffold•Divergent synthesis six (?)-conidiogenones•First total (?)-conidiogenones E, F, 12?-hydroxyconidiogenone C Herein, we constructed fused tetracyclic natural products by single-step tandem cyclizations diazo, allene, olefin moieties in linear precurso...