The establishment of biorelevant and discriminating dissolution procedure for drug products with limited water solubility is a useful technique for qualitative forecasting of the in vivo behavior of formulations. It also characterizes the drug product performance in pharmaceutical development. Lornoxicam, a BCS class-II drug is a nonsteroidal antiinflammatory drug of the oxicam class, has no of...

the effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.a significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, tween 80 and sodium lauryl sulfate (sls). however, asing arlacel 60 as ...

piroxicam (px), an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. thus, the aim of the present study was to improve the solubility and dissolution rate of px by freeze drying technique using dimethylformamide (dmf), chloroform and water as co-solvent system. the prepared crystals containing px were evaluated for dmf and chloroform solvent residual by ga...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

Dissolution testing of the drug formulation introduced in 1960 since then the importance of dissolution test has grown rapidly as have the number of tests and demands in quality control laboratories. Dissolution testing is an official test used by pharmacopeias for evaluating drug release of solid and semisolid dosage forms. The main applications of the dissolution testing include biopharmaceut...

Dissolution kinetics of the (110) face of salicylic acid in aqueous solution is determined by hopping intermittent contact scanning electrochemical microscopy (HIC-SECM) using a 2.5 μm diameter platinum ultramicroelectrode (UME). The method operates by translating the probe UME towards the surface at a series of positions across the crystal and inducing dissolutio n via the reduction of protons...

Abstract Drilling related to development of the platinum-group element deposit J-M Reef Stillwater Complex returned samples a rare chromitite seam between anorthosite and norite in discordant anorthositic body. Plagioclase core An concentrations are marginally higher modestly reversely zoned on side (average Ancore = 83·8; average – Anrim –1·1) as compared with 82·5; +1·0). The anorthosites als...

The red beds of the Buntsandstein (Early Triassic) in Campine Basin (NE Belgium) display porosities between 5.3–20.2% (average 13.7%) and permeabilities varying 0.02–296.4 mD 38.7 mD). Knowledge their reservoir controlling properties, which today are missing, is important view potential geological storage CO2 or natural gas geothermal within these sandstones. Therefore effects diagenesis were a...

A new specific, accurate, precise, and reproducible selective online dissolution method for rosiglitazone maleate is developed and validated for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The rationale of the method is based on the direct measurement of the absorbance of the analyte in the buffer medium at 242 nm using buffer as blank. Dissolution is achieved on a ...