BACKGROUND High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption. OBJECTIVES a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) the relationship between the type of GEJ and GER demonstrated by 24 hours pH-monitoring; and c) id...

1. Economies differ in their vulnerability to climate change. How does climate change– both in terms of market and non-market damages – affect economic growth, structure and distribution of income? 2. Climate change stipulates capital flows and migration. How does this affect regional economies? 3. The risk of climate disruption induces mitigation as well as on anticipated adaptation to climate...

In the context of reproductive risk assessment for birds and mammals endocrine disrupting substances can be defined as substances that cause effects on bird and mammal reproduction through the disruption of endocrine processes. The environmental risk assessment performed under the current guidance document is based on the ecological relevance of the observed effects, independent of the mode of ...

Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the ...

Background: Bilateral rupture of the patellar tendon is a very rare injury, which takes place in relation to chronic systemic diseases. These injuries are known causes. Some of these causes are particular in patellar tendon rupture and another are in quadriceps tendon rupture. Case presentation: 70-year-old diabetic man with simultaneous bilateral patellar tendon disruption of proximal inser...

7 Monograph Over the last two decades, there has been increasing scientific concern and public debate regarding the adverse effects of chemical pollutants in the environment that can interfere with the normal functioning of the endocrine system in wildlife and in humans (the so-called endocrine-disrupting chemicals, EDCs). These concerns have been fueled primarily by reports of disrupted reprod...

Supply chains are exposed to different risks, which can be mitigated by various strategies based on the characteristics and needs of companies. In collaboration with Ford, we develop a decision support framework choose best mitigation strategy against supply disruption risk, especially for companies operating small supplier base low inventory levels. Our is multistage stochastic programming mod...