The dynamics of the PYP photocycle have been studied using time-resolved optical rotatory dispersion (TRORD) spectroscopy in the visible and far-UV spectral regions to probe the changes in the chromophore configuration and the protein secondary structure, respectively. The changes in the secondary structure in PYP upon photoisomerization of the chromophore can be described by two exponential li...

In a recent study on the optical rotatory dispersion of proteins with improved spectropolarimetric techniques, the negative Cotton effect with the trough in the optical rotatory dispersion curves at 233 rnp was investigated (1). According to Simmons, Blout, et al. (2, 3), the amplitude of this effect is related to the amount of the a-helical conformation. The same seems to be true of the positi...

background: metal ions effect on homeostasis of alzheimer’s disease (ad) patients. the aim of this study was to assess the metal ions (iron, zinc and copper) and cbc in patients with ad in comparison with normal range. methods: the samples of study were 17 patients with ad in tehran’s aging centers in 2015, selected as an access sample. blood samples were analyzed in a pathobiology laboratory. ...

Introduction: Klotho and dipeptidyl peptidase-4 (DPP4) are two proteins that modulate inflammatory pathways. We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer disease (AD). Methods: This study was conducted on 16 AD patients and 16 healthy age-matched controls. Plasma levels of tumo...

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In this paper, a new structure is provided for the dispersion compensating photonic crystal fibers in order to broaden the chromatic dispersion and increase the dispersion compensating capability in a wide wavelength range. In the structure, putting elliptical holes in the first ring of the inner core clad of a dispersion compensating fiber of the hexagonal lattice, increases the wavelength ran...