High-protein-low-carbohydrate (HP-LC) diets have become widespread. Yet their deleterious consequences, especially on glucose metabolism and arteries, have already been underlined. Our previous study (2) has already shown glucose intolerance with major arterial dysfunction in very old mice subjected to an HP-LC diet. The hypothesis of this work was that this diet had an age-dependent deleteriou...

Dengue virus (DENV) is among the most important human arboviruses and is clinically and experimentally associated with lipid metabolism disorders. Using high-resolution respirometry, we analyzed the metabolic switches induced by DENV in a human hepatic cell line. This experimental approach allowed us to determine the contribution of fatty acids, glutamine, glucose, and pyruvate to mitochondrial...

The endoplasmic reticulum (ER) is an organelle present in most eukaryotic cells and plays a pivotal role in lipid metabolism. ER dysfunction, specifically ER stress (ERS), is a pathophysiological response involved in lipid metabolism and cardiovascular lesions. Therefore, suppression of ERS may improve lipid metabolic disorders and reduce cardiovascular risk. Herein, we focus on novel breakthro...

OBJECTIVE: Streptozotocin (STZ) destroys the beta cells of pancreas by generation of reactive oxygen species and vitamin C has documented antioxidant properties. This study was designed to evaluate the preventive effect of supplementation of diet by vitamin C on induction of STZ-diabetes and its effect on carbohydrate and lipid metabolism of diabetic rats. MATERIALS AND METHODS: Fifty male Wis...

Several studies have investigated the beneficial effects of dehydroepiandrosterone (DHEA) on lipid and glucose metabolism. However, many of these studies are inconclusive about the effects of DHEA administration on metabolic disorders, and there appear to be sex-related differences in the effects of DHEA treatment. Few animal studies have addressed the effects of DHEA on diet-induced metabolic ...

It is known that carbohydrate metabolism is connected with calcium metabolism and that some disturbances of calcium metabolism can play the definite role in the pathogenesis of diabetes mellitus [1,2]. The changing of insulin secretion was found under hypo-and hyperparathyroidism [3], hypocalcemia, induced by parathyroidectomy [4], primary hyperparathyroidism with hyper calcemia [5]. The preval...

It is known that carbohydrate metabolism is connected with calcium metabolism and that some disturbances of calcium metabolism can play the definite role in the pathogenesis of diabetes mellitus [1,2]. The changing of insulin secretion was found under hypo-and hyperparathyroidism [3], hypocalcemia, induced by parathyroidectomy [4], primary hyperparathyroidism with hyper calcemia [5]. The preval...

Obesity during pregnancy contributes to the development of metabolic disorders in offspring. Maternal exercise may limit gestational weight gain and ameliorate these programming effects. We previously showed benefits of post-weaning voluntary exercise in offspring from obese dams. Here we examined whether voluntary exercise during pregnancy influences lipid and glucose homeostasis in muscle and...

the field of endocrine pharmacology is very wide but most of studies in the recent years from the world and iran have focused on diabetes, osteoporosis, and lipid disorders. in the present review, we tried to evaluate the improvements and publications in that field briefly. interestingly, many of studies have focused on agents that have traditional and natural origin. although few basic studies...

The overuse of glucocorticoid may cause the metabolic disorders affecting the long term outcome of liver transplantation. This study aims to investigate the immune adjustment strategy by decreasing use of glucocorticoid after liver transplantation. The follow-up study was carried out on liver function and lipid metabolism. This study included adult recipients of liver transplantation. There wer...