We establish a solution to the Monge problem in N , with an asymmetric, strictly convex norm cost function, when the initial measure is absolutely continuous. We focus on the strategy, based on disintegration of measures, initially proposed by Sudakov. As known, there is a gap to fill. The missing step is completed when the unit ball is strictly convex, but not necessarily differentiable nor un...

Dissolution rate of two fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) was analysed in presence/absence of three antacid formulations. Disintegration time and neutralisation capacity of antacid tablets were also checked. Variation in disintegration time indicated the importance of this parameter, and allowed evaluation of the influence of postponed antacid-fluoroquinolone contact....

Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. The objective of the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Mouth dissolving tablets (MDTs) were prepared by di...

Potential energy released from the capsize of ice-shelf fragments (icebergs) is the immediate driver of the brief explosive phase of ice-shelf disintegration along the Antarctic Peninsula (e.g. the Larsen A, Larsen B and Wilkins ice shelves). The majority of this energy powers the rapidly expanding plume of ice-shelf fragments that expands outward into the open ocean; a smaller fraction of this...

The aim of this study was to prepare, using taste-masked granules, tablets which can rapidly disintegrate in saliva (rapidly disintegrating tablet), of drugs with bitter taste (pirenzepine HCl or oxybutynin HCl). The taste-masked granules were prepared using aminoalkyl methacrylate copolymers (Eudragit E-100) by the extrusion method. None of the drugs dissolved from the granules (% of dissolved...

Purpose: To formulate simvastatin orodispersible tablets with high dissolution rate and enhanced bioavailability. Methods: Simvastatin solid dispersions in βcyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios by kneading and solvent evaporation methods. Compatibility was investigated by Differential scanning calorimetry (...

To expand the application of a drug in orally disintegrating tablets, the potential use of beta-cyclodextrin (beta-CyD) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) as excipients for the tablets containing dl-alpha-tocopheryl acetate (VE), an oily drug, was evaluated. HP-beta-CyD, not beta-CyD, solubilized VE in water through the formation of higher order of complexes at the molar ratio ...