Let $R$ be a 2-torsion free ring and $U$ be a square closed Lie ideal of $R$. Suppose that $alpha, beta$ are automorphisms of $R$. An additive mapping $delta: R longrightarrow R$ is said to be a Jordan left $(alpha,beta)$-derivation of $R$ if $delta(x^2)=alpha(x)delta(x)+beta(x)delta(x)$ holds for all $xin R$. In this paper it is established that if $R$ admits an additive mapping $G : Rlongrigh...

In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form gamma-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AX(Delta)/Delta) mouse embryonic stem (ES) cells. H2AX(Delta)/Delta ES cells are viable. However, they are highly sensit...

Analysis of retinal development in Delta (Dl) temperature-sensitive mutants reveals requirements for Delta function in the specification of all retinal cells, including photoreceptors, cone cells, pigment cells and cells that make up interommatidial bristles. In situ hybridization and immunohistochemistry indicate that Delta is expressed dynamically during the specification of different cell ty...

Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-alpha, beta/delta, and gamma. PPAR-delta, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-delta is implicated in lipids ...

We consider the 1D nonlinear Schrodinger equation (NLS) with focusing point nonlinearity, \begin{document}$ \begin{equation} i\partial_t\psi + \partial_x^2\psi \delta|\psi|^{p-1}\psi = 0, \;\;\;\;\;\;(0.1)\end{equation} $\end{document} where {\delta} {\delta}(x) is delta function supported at origin. In L^2 supercritical setting p>3 , we construct self-similar blow-up solutions belonging to ene...

Lytic granule exocytosis is the major effector function used by CD8(+) CTL in response to intracellular pathogens and tumors. Despite recent progress in the field, two important aspects of this cytotoxic mechanism remain poorly understood. First, TCR-signaling pathway(s) that selectively induces granule exocytosis in CTL has not been defined to date. Second, it is unclear how Ag receptor-induce...

A detailed comparison of the severity of chest disease with mutational status was carried out by cross sectional study of 127 cystic fibrosis patients, aged 1 to 31 years, living in Wales. Lung disease was classified according to severity, depending on pulmonary function tests (carried out on 76 patients) and chest radiograph status; information was obtained also on age at diagnosis in relation...